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| Correlation Study on Severity of Childhood Depression with Levels of Serum Adrenaline and miR-202 Expression |
| CAO Yuting, CUI Fengwei, WANG Ying |
| Department of Psychiatry, Yancheng Fourth People's Hospital, Yancheng Jiangsu 224003 |
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Abstract 【Objective】To investigate the correlation between levels of serum adrenaline and miR-202 expression and the severity of childhood depression.【Methods】A total of 107 children with depression were included in the observation group. Based on the Children's Depression Inventory (CDI), they were divided into the mild group(34 cases), the moderate group(43 cases) and the severe group(30 cases). An additional 100 healthy children were selected as the control group. Serum adrenaline level and miR-202 expression level were compared between the two groups. Spearman correlation analysis was used to assess the relationship between these levels and the severity of depression. Receiver Operating Characteristic (ROC) curve analysis was used to evaluate the diagnostic value of these markers for childhood depression.【Results】Serum adrenaline level and miR-202 expression level in the observation group were significantly lower than those in the control group (P<0.05). Among the mild, moderate, and severe groups, serum adrenaline level and miR-202 expression level showed a gradual decreasing trend, with significant differences among the groups (P<0.05). Serum adrenaline level and miR-202 expression level were negatively correlated with the severity of depression (P<0.05). The diagnostic efficacy of the combined detection of both serum adrenaline and miR-202 was higher than that of either test alone.【Conclusion】Serum adrenaline level and miR-202 expression are significantly correlated with the severity of childhood depression. Combined detection of both markers has important value for diagnosing and assessing the condition of childhood depression.
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Received: 22 August 2024
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2025, Vol. 42 
