|
|
Clinical Effect of Bronchoalveolar Lavage on Children with Severe Pneumonia |
ZHANG Yale, ZHANG Weihua |
Department of Pediatric Respiratory Medicine,Xianyang Caihong Hospital, Xianyang Shaanxi 712000 |
|
|
Abstract 【Objective】To investigate the clinical effect of bronchoalveolar lavage in the treatment of children with severe pneumonia. 【Methods】 A total of 77 children with severe pneumonia treated and treated in our hospital from December 2019 to March 2022 were selected and divided into observation group (receiving bronchoalveolar lavage, n=40) and control group (not receiving bronchoalveolar lavage, n=37) according to whether the guardians of the children agreed to receive bronchoalveolar lavage. The clinical efficacy, the time of symptom disappearance and the intensity of antibiotic use were compared between the two groups after treatment, and the blood gas indexes before and after bronchoalveolar lavage in the observation group were compared. 【Results】The total effective rate of observation group was 92.50%, which was significantly higher than that of the control group 72.97%(P<0.05). After bronchoalveolar lavage, partial pressure of oxygen in arterial blood(PaO2), oxygenation index(PaCO2/FiO2) were significantly increased and partial pressure of carbon dioxide in arterial blood(PaCO2) was significantly decreased in the observation group, with statistical significance (P<0.05). The time of cough and sputum improvement, fever remission and hospital stay in the observation group were shorter than those in the control group (P<0.05). After 7 and 10 days of treatment, the antibiotic use intensity in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】Bronchoalveolar lavage in children with severe pneumonia in the early stage of clinical treatment, the clinical effect is remarkable, the symptom improvement time is shortened, the blood gas index is significantly improved, and the intensity of antibiotic use is reduced. It is recommended to treat children with severe pneumonia in the early stage of bronchoalveolar lavage.
|
Received: 17 August 2023
|
|
|
|
|
[1] 中华人民共和国国家卫生健康委员会.儿童社区获得性肺炎诊疗规范(2019年版)[J].中国实用乡村医师杂志,2019,26(4):6-13. [2] 国家卫生计生委合理用药专家委员会儿童用药专业组.中国儿童肺炎支原体感染实验室诊断规范和临床实践专家共识(2019年)[J].中华儿科杂志,2020,58(5):366-373. [3] 孙红,孙红妹.肺炎支原体直接损伤及其免疫学致病机制研究进展[J].中华微生物学和免疫学杂志,2015,31(1):65-68. [4] 王菲,张晗,王植嘉,等.难治性肺炎支原体肺炎支气管镜肺泡灌洗术治疗时机研究[J].中国实用儿科杂志,2015,31(11):855-858. [5] 王娟,孙军,高长龙,等.纤维支气管镜肺泡灌洗术治疗儿童难治性支原体肺炎疗效分析[J].临床儿科杂志,2017,35(1):16. [6] 彭力,钟礼立,黄振,等.儿童肺炎支原体肺炎合并外周血淋巴细胞计数减少的临床分析[J].中国当代儿科杂志,2021,23(1):74-77. [7] GAO M, WANG K, YANG M Y, et al.Transcriptome analysis of bronchoalveolar lavage fluid from children with mycoplasma pneumoniae pneumonia reveals natural killer and T cell-proliferation responses[J].Front Immunol,2018,9:1403. [8] 龙煜雯,李渠北.儿童感染性肺不张治疗进展[J].儿科药学杂志,2016,22(5):61-64. [9] GONCALVES R, GATA L, BRETT A.Mycoplasma pneumoniae-associated mucositis[J].BMJ Case Rep,2021,14(4):e239086. [10] CHOI Y J, JEON J H, OH J W.Critical combination of initial markers for predicting refractory mycoplasma pneumoniae pneumonia in children: a case control study [J].Respir Res,2019, 20(1):193. [11] 国家卫生健康委员会人才交流服务中心儿科呼吸内镜诊疗技术专家组,中国医师协会儿科医师分会内镜专业委员会,中国医师协会内镜医师分会儿科呼吸内镜专业委员会,等.中国儿科可弯曲支气管镜术指南(2018年版)[J].中华实用儿科临床杂志,2018,33(13):983-989. [12] 王崇杰,耿刚,李莹,等.支气管肺泡灌洗术治疗时机对重症支原体肺炎伴肺不张患儿影像学恢复的影响[J].重庆医科大学学报,2019,44(5):649-652. [13] 龙婷文,林继雷,代继宏.支气管肺泡灌洗术对肺炎支原体肺炎伴肺不张患儿治疗效果的影响因素分析[J].中国当代儿科杂志,2020,22(9):984-989. [14] DE M P, CAMARGOS P, MASCARENHAS R F, et al.Cell count and lymphocyte immunophenotyping of bronchoalveolar lavage fluid in healthy Brazilian children(Letter)[J].Eur Respir J,2011,38(3):738-739. [15] 陈佳怡,张晗,尚云晓.肺炎支原体肺炎支气管肺泡灌洗液中23S rRNA耐药基因阳性患儿的临床及支气管镜下特点[J].中华实用儿科临床杂志,2022,37(12):897-902. |
|
|
|