ATX、RPR、miR-122与慢性乙型肝炎患者肝纤维化的相关性

doi:10.3969/j.issn.1671-7171.2023.08.029

Abstract
Figure/Table
References (0)
Related Citation (15)

Download: PDF (1192 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the correlation between autotaxin (ATX),RDW-to-Platelet Ratio,RPR (RPR),microRNA-122 (miR-122),and liver fibrosis in patients with chronic hepatitis B (CHB). 【Methods】 A total of 64 CHB patients admitted to our hospital from May 2019 to November 2021 were selected as the study subjects. According to Scheuer's grading criteria,they were divided into a non fibrosis group (S₀ grade,n=12),a mild fibrosis group (S₁-S₂ grade,n=27),and a moderate to severe fibrosis group (S₃-S₄ grade,n=25). The levels of serum ATX,RPR,miR-122,liver fibrosis indicators [hyaluronic acid (HA),laminin (LN),N-terminal peptide of type Ⅲ procollagen (PⅢP),Ⅳ collagen (Ⅳ-C)],and liver hardness were compared among each group. We analyzed the correlation between serum indicators and liver fibrosis indicators,liver hardness,and their diagnostic value for liver fibrosis.【Results】Compared with the non fibrosis group,the levels of serum ATX and RPR in the mild fibrosis group and the moderate to severe fibrosis group increased,while the levels of HA,LN,P Ⅲ P,Ⅳ-C,and liver hardness increased. The expression of miR-122 decreased (P<0.05),and the differences in various indicators between the mild fibrosis group and the moderate to severe fibrosis group were statistically significant (P<0.05). ATX and RPR were positively correlated with HA,LN,PⅢP,Ⅳ-C,and liver hardness (P<0.05),while miR-122 was negatively correlated with HA,LN,PⅢP,Ⅳ-C,and liver hardness (P<0.05). The AUC of ATX,RPR,and miR-122 combined detection for liver fibrosis was higher than that of single detection (P<0.05); The risk of liver fibrosis in patients with high expression of ATX and RPR was 1.604 times and 1.738 times higher than that in patients with low expression (P<0.05),respectively. The risk of liver fibrosis in patients with low expression of miR-122 was 1.887 times higher than that in patients with high expression (P<0.05). 【Conclusion】 As the degree of liver fibrosis worsens in CHB patients,ATX and RPR increase,while miR-122 expression decreases,which is related to liver fibrosis indicators and liver hardness,and has important diagnostic value for the occurrence of liver fibrosis.

Key words： Hepatic Fibrosis Hepatitis B,Chronic Erythrocyte Indices Platelet Count MicroRNAs

Received: 02 September 2022

PACS:

R575.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Xiao
	WANG Xiao-mei

Cite this article:

ZHOU Xiao,WANG Xiao-mei. The Correlation between ATX,RPR,miR-122 and Chronic Hepatitis B Liver Fibrosis[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1221-1224.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.08.029 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I8/1221

[1] 张荣荣,周瑾,赵鹏,等.剪切波弹性成像与血清肝纤维化指标无创评估慢性乙型肝炎患者肝纤维化效能比较[J].肝脏,2021,26(3):255-258.
[2] 魏铁军,张恒,郭艺静,等.慢性丙型肝炎患者血清ATX水平与肝纤维化程度的关系研究[J].胃肠病学和肝病学杂志,2018,27(7):734-738.
[3] 赵小军.红细胞体积分布宽度与血小板比值在慢性乙型肝炎患者肝纤维化评估中的临床价值[J].检验医学与临床,2021,18(15):2278-2281.
[4] 李华忠,蔡笃雄,陈才利.乙型肝炎肝纤维化患者血清miR-122与miR-17表达及其对肝纤维化的预测作用分析[J].标记免疫分析与临床,2021,28(9):1542-1548.
[5] 丁荣蓉,陆伟,王雁冰,等.采用瞬时弹性成像技术和血清标志物预测丙氨酸转氨酶轻度升高的慢性乙型肝炎患者肝纤维化程度[J].中华传染病杂志,2019,37(2):72-76.
[6] 中华医学会感染病学分会,中华医学会肝病学分会.慢性乙型肝炎防治指南(2019年版)[J].中华肝脏病杂志,2019,27(12):938-961.
[7] 陆长春,丁敏侠.血清活性ALDH和ADH水平变化预测老年CHB患者肝纤维化进展的价值[J].中国实验诊断学,2020,24(7):1135-1137.
[8] 李丹,张才江.溶血磷脂酸受体、自分泌运动因子在肝硬化肝性脑病患者中的表达及意义[J].肝脏,2020,25(3):313-316.
[9] 余卫中,张刚,甘洪颖.血清自分泌运动因子诊断非酒精性脂肪肝合并肝纤维化的价值研究[J].临床内科杂志,2020,37(11):789-791.
[10] 杨寸芯,张贺彬,黄国庆,等.二维超声斑点追踪显像技术评估肝硬化患者左心室功能及其与RPR、APRI关系分析[J].浙江医学,2021,43(5):502-506.
[11] 张小燕.慢性肝病患者血清miRNA-122变化及与肝功能、肝纤维化的关系分析[J].检验医学与临床,2020,17(15):2219-2221.
[12] 贾学友,藏小晴.血清miR-122水平对慢性丙型肝炎患者肝纤维化程度的诊断价值[J].医学临床研究,2021,38(3):403-405.