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| Effect of High-purity Urinary Gonadotropin Combined with Letrozole in the Treatment of Infertility Patients with Polycystic Ovary Syndrome |
| LIU Xing-bu, LEI Sheng-yun, YANG Bao-ling |
| Department of Obstetrics and Gynecology, Staff Hospital, Bureau of Geology and Mineral Exploration and Development of Shaanxi Province, Xi'an Shaanxi 710054 |
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Abstract 【Objective】 To investigate the effect of high-purity urinary tropulin (Hp-HMG) combined with letrozole in the treatment of infertility patients with polycystic ovary syndrome. 【Methods】 Eighty infertility patients with polycystic ovary syndrome who were treated in our hospital from January 2016 to October 2020 were enrolled. The patients were divided into Hp-HMG plus letrozole group and Hp-HMG group according to the touch ball method. Hp-HMG group received Hp-HMG 75-150 U/d treatment (for 7 consecutive days), Hp-HMG plus letrozole group received letrozole 2.5 mg/d (for 3 consecutive days) plus Hp-HMG 75-150 U /d (for 4 consecutive days). The blood lipid levels, uterus and follicular conditions, ovulation, pregnancy, and adverse reactions were observed. 【Results】 There was no significant difference in serum lipid levels between the two groups before treatment (P>0.05). After treatment, the levels of TC and TG in Hp-HMG plus letrozole group were significantly lower than those in the Hp-HMG group (P<0.05). There was no significant difference in LDL and HDL between the two groups (P>0.05). There were no significant differences in the thickness of endometrium and uterine volume between the two groups before and after treatment (P>0.05). After treatment, the number of mature follicles, the average diameter of mature follicles, the maximum follicle diameter, the number of 10-14 cm follicles, and the number of >14 cm follicles in Hp-HMG plus letrozole group were higher than those in Hp-HMG group (P<0.05). The number of ovulation and the clinical pregnancy rate of Hp-HMG plus letrozole group were higher than those of Hp-HMG group, the difference was statistically significant (P<0.05). There were no ovarian hyperstimulation syndrome, unruptured follicular luteinization syndrome and abnormal blood routine in both groups. One case of redness was found in the Hp-HMG group. 【Conclusion】 Hp-HMG combined with letrozole is safe in the treatment of polycystic ovary syndrome infertility, and can improve ovulation rate and pregnancy rate and improve blood lipid levels.
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Received: 08 March 2021
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2021, Vol. 38 
