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| Relationship of MMP-9, MIG and Fibroin A Expression with Prognosis of Colon Cancer |
| YIN Chao, WANG Yu-peng |
| Department of General Surgery, The Fourth People's Hospital of Shaanxi, Xi'an Shaanxi, 710043 |
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Abstract 【Objective】 To investigate the relationship of matrix metalloproteinase-9 (MMP-9), migration-inducible protein-7 (MIG-7) and fibroin A (FLNa) expression with pathological factors and disease-free survival (DFS) in patients with colon cancer. 【Methods】 A total of 160 patients with colon cancer admitted to the Fourth People's Hospital of Shaanxi Province for surgery were selected. The postoperative colon cancer tissues was collected to detect MMP-9, MIG-7and FLNa expression by immunohistochemistry in cancer tissues and adjacent tissues. The correlation of MMP-9, FLNa and MIG-7 expression with colon cancer pathological factors and DFS was analyzed. 【Results】 Compared to colon cancer adjacent tissues, the expression levels of MMP-9 and MIG-7 were up-regulated (P<0.05), while the expression level of FLNa was down-regulated (P<0.05). Compared to patients with stage Ⅰ-Ⅱcolon cancer, non-lymph node metastasis and no vascular invasion, the expression levels of MMP-9 and MIG-7 in the tissues of colon cancer patients with stage Ⅲ, lymph node metastasis, and vascular invasion were up-regulated (P<0.05), and the expression of FLNa was down-regulated (P<0.05). The median follow-up time was 18.9 months. There were 25 relapses, 20 metastases, and 9 deaths. COX multivariate analysis showed that MMP-9, MIG-7, FLNa, TNM staging and lymph node metastasis were independent influencing factors of DFS in colon cancer patients (P<0.05). 【Conclusion】 The expression levels of MMP-9 and MIG-7 are up-regulated in colon cancer, and the expression of FLNa is down-regulated. These gene expression levels are related to pathological factors and DFS in colon cancer patients.
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Received: 12 May 2020
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2021, Vol. 38 
