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| Correlation between Infertility Pressure and Cortisol Level in Women with In Vitro Fertilization |
| ZHOU Peng-fei, WANG Cheng-xiu |
| Department of Laboratory Medicine, Baoji Maternal and Child Health Hospital, Baoji 721000 |
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Abstract 【Objective】To investigate the correlation between infertility pressure and cortisol level (COR) in women undergoing in vitro fertilization(IVF).【Methods】During June 2016 and January 2018, 237 couples who received IVF or intracytoplasmic sperm injection (ICSI) in our reproductive center were included in the study. Fertility Problem Inventory (FPI) was used to measure the infertility pressure of the subjects. Serum cortisol levels were measured by chemiluminescence assay. Pearson's correlation was used to compare the correlation between infertility pressure and serum cortisol level. Logistic regression was used to analyze the risk factors of pregnancy outcome in IVF patients.【Results】The average age of 237 women was (33.8±4.3) years old. The BMI was (24.14±3.17) kg/m2, and the infertility time was (2.73±1.14) years. The infertility pressure score of IVF patients was (183.47±24.27) points, and the serum COR level was (4.73±0.26) ng/mL. The correlation analysis showed that infertility pressure score was positively correlated with serum cortisol level ( P< 0.05, with Pearson's correlation coefficient r=0.878). The total fertilization rate of 237 infertile patients undergoing IVF treatment was 65.71%, and the clinical pregnancy rate was 51.24%. Multivariate logistic regression analysis showed that aged≥30 years old, smoking, alcohol consumption, high infertility pressure, and high serum cortisol level were independent risk factors for in vitro fertilization and clinical pregnancy failure (P< 0.05). 【Conclusion】Women receiving IVF treatment have higher infertility pressure and cortisol levels. Fertilization rate and clinical pregnancy rate decreased with the increase of infertility pressure and cortisol level.
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Received: 05 March 2020
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2021, Vol. 38 
