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| Diagnostic Value of Immune-related Indicators and Nuclear Antigen Antibodies in Patients with Systemic Lupus Erythematosus |
| YAN Xiao-qing, ZHOU Ying, ZHU Jin-wu |
| Clinical Laboratory, Shanghai Jiading District Hospital of Traditional Chinese Medicine,Shanghai 201899 |
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Abstract 【Objective】To investigate the diagnostic value of immune-related indicators and nuclear antigen (ENA) antibodies in patients with systemic lupus erythematosus (SLE). 【Methods】A total of 80 patients with SLE were selected and divided into the active group (35 cases) and the inactive group (45 cases) according to the disease activity condition. Forty healthy volunteers were selected as the control group. Peripheral blood immune related indicators (IgA, IgM, IgG, C3, C4) and ENA antibodies (anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB, anti-nRNP) were examined and compared among the tree groups. The ROC curve was used to analyze the diagnostic value of relevant indicators for active SLE . 【Results】 There were significant differences in IgA, IgM, C3, C4, IgG, anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB and anti-nRNP among the three groups ( P <0.05). The levels of IgA, IgM and IgG in the active group were higher than those in the control group and the inactive group; while levels of C3 and C4 were lower than those in the control group and the inactive group ( P <0.05). The IgA and IgG levels in the inactive group were higher than those in the control group, and C3 level in the inactive group was lower than that in the control group ( P <0.05). The positive rates of anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB and anti-nRNP in the active and inactive groups were higher than those in the control group ( P <0.05). There was no significant difference in the positive rate of each individual ENA antibody between the inactive group and the active group ( P >0.05). The optimal critical point for IgA diagnosis of SLE 4.5g/L. When IgA was 4.5 g/L, the sensitivity of IgA in the diagnosis of SLE was 71.5%, the specificity was 80.1%, and the area under the AUC curve was 0.81. 【Conclusion】Immunologically relevant indicators and ENA antibodies have higher diagnostic value in patients with SLE, and IgA, IgG and C3 can better indicate the progress.
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Received: 12 June 2019
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2021, Vol. 38 
