Abstract 【Objective】To investigate the diagnostic value of immune-related indicators and nuclear antigen (ENA) antibodies in patients with systemic lupus erythematosus (SLE). 【Methods】A total of 80 patients with SLE were selected and divided into the active group (35 cases) and the inactive group (45 cases) according to the disease activity condition. Forty healthy volunteers were selected as the control group. Peripheral blood immune related indicators (IgA, IgM, IgG, C3, C4) and ENA antibodies (anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB, anti-nRNP) were examined and compared among the tree groups. The ROC curve was used to analyze the diagnostic value of relevant indicators for active SLE . 【Results】 There were significant differences in IgA, IgM, C3, C4, IgG, anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB and anti-nRNP among the three groups ( P <0.05). The levels of IgA, IgM and IgG in the active group were higher than those in the control group and the inactive group; while levels of C3 and C4 were lower than those in the control group and the inactive group ( P <0.05). The IgA and IgG levels in the inactive group were higher than those in the control group, and C3 level in the inactive group was lower than that in the control group ( P <0.05). The positive rates of anti-ds-DNA, anti-Sm, anti-SSA, anti-SSB and anti-nRNP in the active and inactive groups were higher than those in the control group ( P <0.05). There was no significant difference in the positive rate of each individual ENA antibody between the inactive group and the active group ( P >0.05). The optimal critical point for IgA diagnosis of SLE 4.5g/L. When IgA was 4.5 g/L, the sensitivity of IgA in the diagnosis of SLE was 71.5%, the specificity was 80.1%, and the area under the AUC curve was 0.81. 【Conclusion】Immunologically relevant indicators and ENA antibodies have higher diagnostic value in patients with SLE, and IgA, IgG and C3 can better indicate the progress.
YAN Xiao-qing,ZHOU Ying,ZHU Jin-wu. Diagnostic Value of Immune-related Indicators and Nuclear Antigen Antibodies in Patients with Systemic Lupus Erythematosus[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 359-361.
[1] Rua-Figueroa FDLI.What is new in systemic lupus erythematosus[J]. Reumatol Clin, 2015,11(1):27-32. [2] Adinolfi A, Valentini E, Calabresi E, et al . One year in review 2016: systemic lupus erythematosus[J]. Clin Exp Rheumatol, 2016,34(4):569-574. [3] Errante PR, Perazzio SF, Frazao JB, et al . Primary immunodeficiency association with systemic lupus erythematosus: review of literature and lessons learned by the Rheumatology Division of a tertiary university hospital at Sao Paulo, Brazil[J]. Rev Bras Reumatol Engl Ed, 2016,56(1):58-68. [4] 石连杰,李春,朱佳鑫, 等.系统性红斑狼疮最新分类标准解读[C].//中国免疫学会.第八届全国免疫学学术大会论文集,2012:446. [5] Ichinose K.Unmet needs in systemic lupus erythematosus[J]. Nihon Rinsho Meneki Gakkai Kaishi, 2017,40(6):396-407. [6] Sebastiani GD, Prevete I, Iuliano A, et al . The Importance of an Early Diagnosis in Systemic Lupus Erythematosus[J]. Isr Med Assoc J, 2016,18(3-4):212-215. [7] 肖榆冰,郭慕瑶,左晓霞.免疫代谢与系统性红斑狼疮[J].北京大学学报(医学版),2018,50(6):1120-1124. [8] 潘为力,杨晓婷.核抗原抗体与体液免疫相关指标联合检测在系统性红斑狼疮诊断中的价值[J].国际免疫学杂志,2018,41(5):519-523. [9] 蒋伟光,孙晓娜.抗可提取核抗原抗体与体液免疫联合检测在系统性红斑狼疮诊断中的应用[J].中国医药指南,2016,14(29):66-67.
2021, Vol. 38 
