E盒结合锌指蛋白2与结肠癌发生发展及预后的关系<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2021.03.012

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1167 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the relationship between E-box binding zinc finger protein 2 (ZEB2) and the development and prognosis of colon cancer. 【Methods】The pathological specimens of 90 colon cancer patients collected from the pathology center of our hospital were selected, and 45 specimens of adjacent colon cancer tissues were selected as the control group. The intensity of ZEB2 protein expression in the two groups was detected by Western-blot technique. The differences of ZEB2 protein expression in colon cancer tissues with different age, gender, lesion diameter, tumor location, TNM stage, tumor differentiation, lymph node metastasis and colon cancer were analyzed by logistic regression. The relationship between ZEB2 protein and prognosis of colon cancer patients was analyzed by logistic regression. 【Results】The expression of ZEB2 protein in colon cancer tissues was higher than that in the control group, and the difference was statistically significant ( P <0.05). ZEB2 protein in colon cancer tissues with different ages, genders, different lesion diameters, different tissue differentiation degrees and different colon sites. There was no statistically significant difference between the expression intensity groups ( P >0.05). The differences in ZEB2 protein expression between the different TNM stages, lymph node metastasis, and 2-year follow-up of different outcomes were statistically significant. ( P <0.05); Logistic regression analysis showed that the higher the TNM stage, the lymph node metastasis and the increased ZEB2 protein expression were independent risk factors for poor prognosis in colon cancer patients ( P <0.05). 【Conclusion】ZEB2 protein expression is up-regulated in colon cancer tissues and is associated with tumor development and prognosis.

Key words： Colonic Neoplasms/PA Zinc Finger E-box-Binding Homeobox 2 Immunohistochemistry Prognosis

Received: 03 September 2019

PACS:

R735.35

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	JIN Hong-qi
	ZHAO Lian-feng

Cite this article:

JIN Hong-qi,ZHAO Lian-feng. Relationship between ZEB2 Protein and Development and Prognosis of Colon Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 362-364.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/362

[1] Aldecoa I, Atares B, Tarragona J, et al . Molecularly determined total tumour load in lymph nodes of stage Ⅰ-Ⅱ colon cancer patients correlates with high-risk factors. A multicentre prospective study[J]. Virchows Arch, 2016,469(4):385-394.
[2] 熊伟,张洪涛,杨之斌,等. LncRNA HCG11通过调控miR-144-3p/ZEB1分子轴影响直肠癌的发生及转移[J].中国肿瘤生物治疗杂志,2019,29(2):173-181.
[3] 秦豫培,胡阳黔. 锌指蛋白217在结肠癌组织中的表达及其临床意义[J].中国现代医学杂志,2017,27(8):38-42.
[4] 中华医学会消化内镜学分会消化系旱癌内镜诊断与治疗协会,中华医学会消化病学分会消化道肿瘤协作组,中华医学会消化内镜学分会肠道学组,等. 中国早期结直肠癌及癌前病变筛查与诊治共识意见(2014年11月·重庆)[J].中华内科杂志,2015,54(4):375-389.
[5] 孙红兰,刘慧峰,姜国丹.p-MTOR 在结肠癌中的表达及与患者病理学特征的关系[J].癌症进展,2018,16(1):70-72.
[6] van Eeghen EE, Bakker SD, van Bochove A, et al. High risk stage 2 and stage 3 colon cancer, predictors of recurrence and effect of adjuvant therapy in a nonselected population[J]. Int Sch Res Notices, 2015:790186.
[7] 李会平,代爱军. 结直肠癌患者术前血清癌胚抗原及糖类抗原19-9阳性与临床病理学特征的关系[J].中国肛肠病杂志,2019,39(1):1-3. [8] 任年胜,朱跃坤,李奭强,等. ZNF281对结直肠癌细胞侵袭与迁移的影响[J].中国医学前沿杂志(电子版),2017,9(03):102-105.
[9] 高阳,尚闯,罗淼. 微小RNA-34a在结直肠癌患者血清及组织中的表达及其与E盒结合锌指蛋白2表达的相关性[J].中华实验外科杂志,2015,32(7):1689-1692.
[10] 何平,高显华,许硕贵,等. 锌指结构蛋白148可变剪切体在结直肠癌发生发展中的作用[J].中国肿瘤生物治疗杂志,2017,24(12):1391-1396.
[11] 秦豫培,胡阳黔. 锌指蛋白217在结肠癌组织中的表达及其临床意义[J].中国现代医学杂志,2017,27(08):38-42.