丙型肝炎病毒患者抗病毒干预持续应答后发生肝细胞肝癌的临床特征<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2021.03.010

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Abstract 【Objective】To investigate the clinical characteristics of hepatitis C virus (HCV) treated with direct-acting antivirals(DAA) patients with hepatocellular carcinoma (HCC) during the sustained virological response (SVR) after antiviral intervention. 【Methods】 A total of 130 patients with HCV infection in our hospital were recruited in the study. All patients were received HCV antiviral therapy and the SVR rate was recorded. The incidence of HCC were followed up after discharge. According to the occurrence of HCC, patients with SVR were further divided into the observation group (occurrence of HCC) and the control group (no occurrence of HCC).The basic data and clinicopathological characteristics were compared between the two groups. The Cox multivariate risk model was used to explore the high risk factors of HCC in patients with SVR after HCV antiviral intervention. 【Results】Among 130 patients with HCV,98 required SVR after HCV antiviral intervention. The SVR rate was 75.38%.There were 6 cases of HCC occurred during the follow-up period, which was 6.12% (6/98).There were significant differences in direct antiviral drugs (DAA) treatment, liver status, AST, ALT and AFP levels among patients with different prognosis, the difference were statistically significant ( P <0.05).The Cox multivariate risk analysis showed that the DAA treatment, liver status and AFP level were the risk factors for HCC after SVR ( P <0.05). 【Conclusion】 The DAA treatment, liver status and AFP level are the independent factors, which affect the occurrence of HCC for the patients with SVR after antiviral therapy.

Key words： Hepatitis C/TH Antiviral Agents Carcinoma Hepatocellular/ET Prognosis

Received: 18 September 2019

PACS:

R735.7

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	Articles by authors
	LIU Dong-yu
	BAI Jie
	ZHANG Wen-hua
	et al

Cite this article:

LIU Dong-yu,BAI Jie,ZHANG Wen-hua, et al. Clinical Analysis of Hepatitis C Virus Patients with Hepatocellular Carcinoma during Sustained Virological Response after Antiviral Intervention[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 356-358.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/356

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