法舒地尔对急性脑梗死患者血清MMP-10、ox-LDL及GSH-Px的影响

doi:10.3969/j.issn.1671-7171.2021.02.023

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Abstract 【Objective】 To investigate the effects of fasudil on MMP-10 (matrix metalloproteinase 10), ox-LDL (ox-LDL) and GSH-Px (glutathione peroxidase) in patients with acute cerebral infarction(ACI). 【Methods】 A total of 100 patients with ACI in our hospital were randomly divided into two groups, each group with 50 cases. Patients with conventional treatment were as the control group, while patients in the observation group received fasudil in addition to the conventional treatment. Serum index levels, neurologic impairment, life activity, clinical efficacy and safety of the two groups were compared. 【Results】 After treatment, the total effective rates for the observation group and the control group were 90% and 64%, respectively. The efficiency of the observation group was significantly higher than that of the control group; the difference was statistical significance (P<0.05). The NIHSS score in the two groups decreased significantly, and the ADL score increased significantly in the two groups as well. However, the NIHSS score in the observation group was lower than that in the control group, ADL score in the observation group was higher than that in the control group; the difference was statistical significance (P<0.05). After treatment, serum MMP-10, ox-LDL and GSH-Px levels were significantly reduced in the two groups, and the reduction level of the observation group was significantly lower than that of the control group (P<0.05). There was no adverse drug effects in the observation group showing good tolerance after treatment. 【Conclusion】 The use of fasudil on the basis of conventional treatment in the clinical treatment of ACI can reduce serum MMP-10, ox-LDL and GSH-Px levels and improve the ability of daily life. It has significant curative effect, no adverse reaction and high safety, which is worthy of clinical application.

Key words： Brain Infarction Acute Disease Vasodilator Agents/TU Matrix Metalloproteinase 10/BL Lipoproteins, LDL/BL

Received: 10 May 2019

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	Articles by authors
	SHEN Yu-hua
	RUAN Qiong-yan
	YANG Qi

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SHEN Yu-hua,RUAN Qiong-yan,YANG Qi. Effects of Fasudil on Serum Levels of MMP-10, ox-LDL and GSH-Px in Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 240-242.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.02.023 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I2/240

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