Abstract 【Objective】To explore the risk factors of vascular dementia (VD) in elderly patients with cerebral infarction. 【Methods】 A total of 193 elderly patients with cerebral infarction were selected for the study. According to the occurrence of VD, the patients were divided into the VD group (74 cases) and the non VD group (119 cases). General data of the two groups were compared. Risk factors for VD were evaluated by Logistic regression analysis, and the diagnostic efficacy of VD was analyzed using receiver operating characteristic curve (ROC). Pearson was used to explore the correlation among various factors and analyze the expression of risk factors in different degrees of dementia. 【Results】The multivariate analysis showed that age (OR=4.926, P <0.05), >6 years of Education ( OR =1.953, P <0.05), infarct area ( OR =5.147, P <0.05), severe vascular stenosis ( OR =3.031, P <0.05), hypertension ( OR =2.853, P <0.05), vascular endothelial growth factor (VEGF) level ( OR =5.452, P <0.05), and brain Neurotrophic factor (BDNF) ( OR =4.524, P <0.05) were independent influencing factors of VD after cerebral infarction. Particularly, age >60 years old, severe stenosis of blood vessels, hypertension, infarct area >7.18 cm2, VEGF<4.47ng/mL and BDNF<236.83 pg/mL patients need to be alert to the occurrence of VD. Correlation analysis showed that age was positively correlated with infarct size and negatively correlated with VEGF and BDNF. VEGF was positively correlated with BDNF. The levels of VEGF and BDNF increased with the severity of dementia, and the number of severe vascular stenosis and the number of hypertension increased with the severity of dementia as well. 【Conclusion】 Elderly patients with older age of primary cerebral infarction, large infarct area, high blood pressure (hypertension), high VEGF and BDNF level increase the probability of VD, while the elderly with more years of education may reduce the risk of VD.
XUE Yan-hua,LI Jing,YU Qi-jin, et al. Risk Factors for Vascular Dementia in Elderly Patients with Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 339-342.
[1] 吉晓天, 陈垂海, 周少珑. 艾宾浩斯遗忘曲线记忆训练在血管性痴呆患者中的疗效探讨[J].医学临床研究, 2017, 34(1):155-156. [2] Sabljak VD, Zivaljevic VR, Milicic BR, et al . Risk factors for intraoperative hypertension during the surgery of primary hyperparathyroidism.[J]. Med Princ Pract, 2017, 26(4):381-386. [3] Gupta S, Singh P, Sharma B.Neuroprotective effects of nicorandil in chronic cerebral hypoperfusion-induced vascular dementia[J]. J Stroke Cerebrovasc Dis, 2016, 25(11):2717-2728. [4] 中华医学会神经病学分会. 中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志, 2015, 48(4):246-257. [5] Hughes CP, Berg L, Danziger WL, et al . A new clinical scale for the staging of dementia[J]. Br J Psychiatry, 1982, 140: 566-572. [6] Srinivasan V, Braidy N, Chan EKW, et al . Genetic and environmental factors in vascular dementia: an update of blood brain barrier dysfunction[J]. Clin Exp Pharmacol Physiol , 2016, 43(5):515-521. [7] Vinters HV, Zarow C, Borys E, et al . Vascular dementia: clinicopathologic and genetic considerations[J]. Neuropathol Appl Neurobiol, 2018, 44(3):247-266. [8] Huang SL, Chang CW, Lee YH, et al . Protective effect of low-intensity pulsed ultrasound on memory impairment and brain damage in a rat model of vascular dementia[J]. Radiology, 2016, 282(1):113-122. [9] Ueno M.Elucidation of mechanism of blood-brain barrier damage for prevention and treatment of vascular dementia[J]. Rinsho Shinkeigaku, 2017, 57(3): 95-109. [10] Wang S, Yang H, Zhang J, et al . Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial[J]. BMC Complemen Altern Med, 2016, 16(1):361. [11] Ritz M F, Grond-Ginsbach C, Kloss M, et al . Identification of inflammatory, metabolic, and cell survival pathways contributing to cerebral small vessel disease by postmortem gene expression microarray[J]. Curr Neurovascr Res, 2016, 13(1):58-67. [12] Failla M D, Conley Y P, Wagner A K.Brain-derived neurotrophic factor (BDNF) in traumatic brain injury-related mortality:interrelationships between genetics and acute systemic and central nervous system BDNF profiles[J]. Neurorehabil Neural Rep, 2016, 30(1):83-93.
2021, Vol. 38 
