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| Value of Neutrophil Level in Differentiating Diagnosis for Different Types of Interstitial Lung Disease |
| HUANG Ren-yuan, SONG Yuan-yuan, YING Han-qiu |
| Xuzhou Medical University,Xuzhou,Jiangsu 221000 |
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Abstract 【Objective】 To explore the value of neutrophil level in differential diagnosis for different types of interstitial lung disease (ILD).【Methods】 A total of 98 ILD patients were admitted to our hospital, including 48 cases of idiopathic interstitial pulmonary fibrosis (IPF-ILD,A group )and 50 cases of connective tissue disease-related ILD (CTD-ILD,B group ). In the same time period, 50 healthy volunteers who underwent physical examination were selected as the control group. The levels of neutrophils in three groups were compared. The ROC curve was drawn to analyze the differential value of neutrophils in different types of ILD.Serum levels of human interferon-gamma induced protein-10 (IP-10), human epithelial cell-derived neutrophil activating peptide-78 (ENA-78) and type I procollagen (PCI) were measured in patients with different types of ILD. The correlation of neutrophil level with serum IP-10, ENA-78 and PCI in patients with ILD was analyzed.【Results】 The levels of neutrophils in ILD patients of both A group and B group were significantly higher than that in the control group (P<0.05).The level of neutrophils in A group was significantly higher than that in B group (P<0.05).The area under the curve of differentiating IPF-ILD and CTD-ILD at neutrophil level was 0.657 (P<0.05).The level of serum IP-10 in A group was significantly higher than that in B group (P<0.05). There was no significant difference in serum ENA-78 and PCI between the two groups (P>0.05). Pearson analysis showed that neutrophil level was positively correlated with serum IP-10 ( P<0.05), but not with ENA-78 and PCI ( P>0.05).【Conclusion】 The level of neutrophils has certain value in differentiating IPF-ILD and CTD-ILD, and it is positively correlated with serum IP-10 in patients with ILD.
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Received: 16 September 2019
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2020, Vol. 37 
