尿肾功能指标在糖尿病肾病早期肾损伤中的评估价值

doi:10.3969/j.issn.1671-7171.2019.05.004

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Abstract 【Objective】To explore the value of urinary and renal function indicators in early renal injury in diabetic nephropathy (DN). 【Methods】Fifty patients with type 2 diabetes mellitus (T2DM) were selected from June 2017 to June 2018. According to the level of urinary microalbumin (MA), patients were divided into diabetic kidney injury group (MA>23 mg/L, observation group,n=18) and diabetic non-kidney injury group (MA<23 mg/L, control group,n=32). The levels of N-acetyl-D-glucosaminidase (NAG), MA, beta-2-microglobulin (beta-2-MG), cystatin-C (Cys-C), retinol binding protein (RBP) were compared between the two groups, and the ROC curves of early DN renal injury were analyzed. 【Results】There was no significant difference in the levels of creatinine (Cr) and blood urea nitrogen (BUN) between the two groups (P>0.05); the levels of NAG, RBP, beta 2-MG and Cys-C in the observation group were higher than those in the control group (P<0.05). The AUCs of NAG, RBP, beta 2-MG and Cys-C in ROC curve were 0.894, 0.926, 0.937 and 0.984 respectively, and those of Cr and BUN were 0.513 and 0.433 respectively.【Conclusion】NAG, RBP, beta 2-MG and Cys-C are highly expressed in patients with early DN renal injury, and they are highly sensitive to the diagnosis of early DN renal injury, which can provide a basis for early diagnosis and treatment of diseases.

Key words： Diabetic Nephropathies/DI Kidney Function Tests

Received: 03 December 2018

PACS:

R587.24

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.05.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I5/843