高频超声检查联合TSH检测在甲状腺癌诊断及其临床病理特征分析中的应用价值

doi:10.3969/j.issn.1671-7171.2026.05.013

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摘要 【目的】探讨高频超声检查联合促甲状腺激素(TSH)检测在甲状腺癌诊断及其临床病理特征分析中的应用价值。【方法】回顾性分析2022年1月至2024年12月郑州市第一人民医院收治的90例甲状腺癌患者(观察组)的临床资料,另选同期郑州市第一人民医院收治的90例甲状腺炎患者(对照组)的临床资料。两组患者均进行了高频超声检查及血清TSH检测。采用受试者工作特征(ROC)曲线分析高频超声检查联合TSH检测对甲状腺癌的诊断价值,并采用Spearman相关性分析高频超声特征、TSH水平与甲状腺癌患者临床病理特征的相关性。【结果】两组内部低回声占比比较,差异无统计学意义(P>0.05)。观察组微钙化灶、边界不清、血流分级2～3级占比及TSH水平均高于对照组,周围无回声和血流分级0～1级占比低于对照组(P<0.05)。高频超声检查联合TSH检测诊断甲状腺癌的敏感度、特异度、曲线下面积(AUC)分别为96.7%、97.8%、0.963,其诊断价值高于高频超声检查、TSH检测。Spearman相关性分析结果显示:肿瘤直径、淋巴结转移、临床分期、肿瘤分化程度、腺外浸润与内部低回声、边界不清、血流分级及TSH水平呈正相关(P<0.05);肿瘤直径、淋巴结转移与微钙化灶、周围无回声呈正相关(P<0.05);临床分期、肿瘤分化程度与微钙化灶、周围无回声呈负相关(P<0.05);腺外浸润与微钙化灶呈负相关(P<0.05)。【结论】高频超声检查联合TSH检测对甲状腺癌具有较高诊断价值,且高频超声特征及TSH水平与甲状腺癌患者的肿瘤直径、淋巴结转移、临床分期等临床病理特征具有显著相关性,可为甲状腺癌的诊断及病情评估提供参考。

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	王少博
	陈轶杰
	胡涌波

关键词 ：甲状腺肿瘤, 超声检查, 促甲状腺素, 诊断, 病理状态,体征和症状

Abstract：【Objective】 To explore the application value of high-frequency ultrasonography combined with thyroid-stimulating hormone (TSH) detection in the diagnosis of thyroid carcinoma and the analysis of its clinicopathological characteristics. 【Methods】 The clinical data of 90 patients with thyroid carcinoma (observation group) admitted to The First People's Hospital of Zhengzhou from January 2022 to December 2024 were retrospectively analyzed, and the clinical data of 90 patients with thyroiditis admitted during the same period were selected as the control group. All patients underwent high-frequency ultrasonography and serum TSH detection. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of combined high-frequency ultrasonography and TSH detection for thyroid carcinoma. Spearman correlation analysis was adopted to explore the correlations of high-frequency ultrasonic features and TSH levels with clinicopathological characteristics of thyroid carcinoma patients. 【Results】 There was no significant difference in the proportion of internal hypoechogenicity between the two groups (P>0.05). The proportions of microcalcification, irregular boundary, blood flow grade 2-3 and TSH level in the observation group were higher than those in the control group, while the proportions of peripheral anechoic area and blood flow grade 0-1 were lower than those in the control group (P<0.05). The sensitivity, specificity and area under the curve (AUC) of combined high-frequency ultrasonography and TSH detection in diagnosing thyroid carcinoma were 96.7%, 97.8% and 0.963 respectively, showing higher diagnostic efficacy than single high-frequency ultrasonography or single TSH detection. Spearman correlation analysis showed that tumor diameter, lymph node metastasis, clinical stage, tumor differentiation degree and extrathyroidal invasion were positively correlated with internal hypoechogenicity, irregular boundary, blood flow grade and TSH level (P<0.05); tumor diameter and lymph node metastasis were positively correlated with microcalcification and peripheral anechoic area (P<0.05); clinical stage, tumor differentiation degree were negatively correlated with microcalcification and peripheral anechoic area (P<0.05);extracellular infiltration is negatively correlated with microcalcification foci. 【Conclusion】 High-frequency ultrasonography combined with TSH detection has high diagnostic value for thyroid carcinoma. Ultrasonic features and TSH levels are significantly correlated with clinicopathological characteristics such as tumor diameter, lymph node metastasis and clinical stage, which can provide reference for the diagnosis and condition evaluation of thyroid carcinoma.

Key words： Thyroid Neoplasms Ultrasonography Thyrotropin Diagnosis Pathological Conditions, Signs and Symptoms

收稿日期: 2025-08-06

中图分类号:

R736.1

引用本文:

王少博, 陈轶杰, 胡涌波. 高频超声检查联合TSH检测在甲状腺癌诊断及其临床病理特征分析中的应用价值[J]. 医学临床研究, 2026, 43(5): 750-753.
WANG Shaobo, CHEN Yijie, HU Yongbo. Application Value of High-Frequency Ultrasonography Combined with TSH Detection in the Diagnosis of Thyroid Carcinoma and Analysis of its Clinicopathological Characteristics. JOURNAL OF CLINICAL RESEARCH, 2026, 43(5): 750-753.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.05.013 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I5/750

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