Abstract：【Objective】 This study aims to explore the application value of combined detection of hepatitis C virus antibody (HCV-Ab), albumin (ALB) and alanine aminotransferase (ALT) in the diagnosis of hepatitis C. 【Methods】 A total of 96 patients who underwent viral hepatitis screening in the hospital from January 2023 to January 2025 were selected as the observation group. Meanwhile, 96 healthy volunteers who received physical examination in the same hospital during the same period were selected as the control group. Venous blood samples were collected from both groups for the laboratory tests. The levels of HCV-Ab, ALB and ALT were compared between the two groups, and the diagnostic efficacy of HCV-Ab and hepatitis C virus ribonucleic acid (HCV-RNA) was analyzed.Plot the receiver operating characteristic (ROC) curve to analyze the diagnostic efficacy of each indicator alone and in combination for hepatitis C. 【Results】 With the HCV-RNA test result as the reference, among the 96 patients in the observation group, 56 were positive for HCV-RNA and 40 were negative; 52 were positive for HCV-Ab and 44 were negative. The HCV-Ab test result showed good consistency with the HCV-RNA test result (Kappa value=0.704). The levels of HCV-Ab and ALT in the observation group were significantly higher than those in the control group, while the ALB level was significantly lower than that in the control group, and all differences were statistically significant (all P<0.05). ROC curve analysis showed that the combination of HCV-Ab, ALB, and ALT for the diagnosis of hepatitis C had an AUC of 0.979 (95%CI: 0.957-1.000), with a sensitivity of 91.7% and specificity of 97.9%, which were significantly superior to those of each single indicator (P<0.05). 【Conclusion】 The combined detection of HCV-Ab, ALB, and ALT can more comprehensively reflect hepatitis C infection and liver function impairment by complementing the strengths of each indicator, thereby providing a more reliable laboratory reference scheme for the clinical diagnosis of hepatitis C.
柳璐璐, 刘秀. 丙肝抗体、白蛋白联合谷丙转氨酶检测在丙型肝炎诊断中的应用价值[J]. 医学临床研究, 2026, 43(5): 769-772.
LIU Lulu, LIU Xiu. Value of Combined Detection of Hepatitis C Virus Antibody, Albumin and Alanine Aminotransferase in Diagnosis of Hepatitis C. JOURNAL OF CLINICAL RESEARCH, 2026, 43(5): 769-772.
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2026, Vol. 43 
