Ⅰ期心脏康复对STEMI患者急诊PCI术后心功能及血清STIM1水平的影响

doi:10.3969/j.issn.1671-7171.2025.12.009

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摘要 【目的】探讨Ⅰ期心脏康复对ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)术后心功能及血清基质交感分子1(STIM1)水平的影响。【方法】选取2024年1月至12月在长海医院和控江医院接受急诊PCI治疗的100例STEMI患者,随机分为对照组和康复组,每组50例。对照组给予急诊PCI术后的常规治疗,康复组在常规治疗基础上进行Ⅰ期心脏康复治疗。比较两组治疗前和治疗1个月后左室射血分数(LVEF)、N末端脑钠肽前体(NT-proBNP)水平、STIM1水平、躯体健康总评(PCS)评分、精神健康总评(MCS)评分、峰值氧摄取(VO₂/kg)、代谢当量(MET)、氧脉搏(VO₂/HR)、通气-二氧化碳排放比(VE/VCO₂斜率)及心血管不良事件发生情况。【结果】治疗1个月后,康复组LVEF、PCS评分、MCS评分高于对照组(P<0.05),血清NT-proBNP和STIM1水平低于对照组(P<0.05)。康复组的峰值VO₂/kg、MET和VO₂/HR均高于对照组(P<0.05),VE/VCO₂斜率低于对照组(P<0.05)。两组心血管不良事件发生率比较,差异无统计学意义(P>0.05)。【结论】Ⅰ期心脏康复对急诊PCI术后STEMI患者具有显著改善作用,其不仅能够有效提高患者心功能,降低心力衰竭发生风险,还能改善患者生活质量,减轻心理负担,并可能通过降低血清中STIM1水平,促进患者康复,具有较好的临床推广价值。

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关键词 ：心脏康复, ST段抬高型心肌梗死, 急性病, 经皮冠状动脉介入治疗, 心脏功能试验

Abstract：【Objective】 To investigate the effect of Phase Ⅰ cardiac rehabilitation on cardiac function and serum stromal interaction molecule 1 (STIM1) level in patients with ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). 【Methods】 A total of 100 STEMI patients who underwent emergency PCI in the Changhai Hospital and the Kongjiang Hospital from January to December 2024 were selected and randomly divided into a control group and a rehabilitation group, with 50 cases in each group. The control group received routine treatment after emergency PCI, while the rehabilitation group received Phase Ⅰ cardiac rehabilitation on the basis of routine treatment. Left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP) level, STIM1 level, physical component summary (PCS) score, mental component summary (MCS) score, peak oxygen uptake (VO₂/kg), metabolic equivalent (MET), oxygen pulse (VO₂/HR), ventilation-to-carbon dioxide production ratio (VE/VCO₂ slope) and the occurrence of major adverse cardiovascular events (MACE) were compared between the two groups before treatment and 1 month after treatment. 【Results】 One month after treatment, the LVEF, PCS score and MCS score in the rehabilitation group were significantly higher than those in the control group (P<0.05), while the serum levels of NT-proBNP and STIM1 were significantly lower than those in the control group (P<0.05). The peak VO₂/kg, MET and VO₂/HR in the rehabilitation group were higher than those in the control group (P<0.05), and the VE/VCO₂ slope was lower than that in the control group (P<0.05). There was no significant difference in the incidence of MACE between the two groups (P>0.05). 【Conclusion】 Phase Ⅰcardiac rehabilitation has a significant improvement effect on STEMI patients after emergency PCI. It can not only effectively improve cardiac function, reduce the risk of heart failure, but also enhance the quality of life and alleviate psychological burden of the patients. It may also promote patient recovery by reducing serum STIM1 level, which has good clinical promotion value.

Key words： Cardiac Rehabilitation ST Elevation Myocardial Infarction Acute Disease Percutaneous Coronary Intervention Heart Function Tests

收稿日期: 2025-02-19

中图分类号:

R542.22

基金资助:上海市杨浦区卫生健康委员会科研课题(编号:YPQ202305)

通讯作者: **E-mail:zhaoyaj2000@aliyun.com

引用本文:

钱一君, 张越月, 倪烨, 张必利, 赵娅. Ⅰ期心脏康复对STEMI患者急诊PCI术后心功能及血清STIM1水平的影响[J]. 医学临床研究, 2025, 42(12): 2046-2049.
QIAN Yijun, ZHANG Yueyue, NI Ye, et al. Effect of Phase Ⅰ Cardiac Rehabilitation on Cardiac Function and Serum STIM1 Level in STEMI Patients after Emergency PCI. JOURNAL OF CLINICAL RESEARCH, 2025, 42(12): 2046-2049.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.12.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I12/2046

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