Clinical Efficacy of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Bilateral Dorsolateral Prefrontal Cortex in Patients with Post-Ischemic Stroke Insomnia
ZHANG KaiLi, LI MingHong, LI Ye, et al
Department of Rehabilitation Medicine, Affiliated Hospital of Xinyang Vocational and Technical College, Xinyang Henan 464000
Abstract：【Objective】 To explore the clinical efficacy of low-frequency repetitive transcranial magnetic stimulation(rTMS) on bilateral dorsolateral prefrontal cortex(DLPFC) in the treatment of patients with insomnia after ischemic stroke.【Methods】 A total of 90 patients with post-ischemic stroke insomnia treated in our hospital from August 2022 to October 2023 were selected and randomly divided into the observation group and the control group by envelope method, with 45 cases in each group. The control group received routine basic treatment for stroke and rehabilitation nursing, while the observation group was additionally given low-frequency rTMS treatment on the basis of the control group. The sleep quality [Pittsburgh Sleep Quality Index(PSQI) score] and polysomnography monitoring indicators [total sleep time(TST), sleep efficiency(SE), sleep latency(SL), rapid eye movement sleep(REM), non-rapid eye movement sleep stage 1(N1), non-rapid eye movement sleep stage 2(N2), non-rapid eye movement sleep stage 3(N3)] were compared between the two groups before and after treatment.【Results】 After treatment, the PSQI score of the observation group was significantly lower than that of the control group(P<0.05). The TST, REM, N2, and N3 of the observation group were longer than those of the control group; the SL and N1 were shorter than those of the control group; the SE was higher than that of the control group, with statistically significant differences(P<0.05).【Conclusion】 Low-frequency rTMS on bilateral DLPFC in the treatment of patients with post-ischemic stroke insomnia can significantly improve the patients' sleep status.
张楷利, 李明鸿, 李烨, 高伟, 邱景. 低频重复经颅磁刺激双侧背外侧前额叶皮层治疗缺血性脑卒中后失眠患者的临床疗效[J]. 医学临床研究, 2025, 42(9): 1559-1561.
ZHANG KaiLi, LI MingHong, LI Ye, et al. Clinical Efficacy of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Bilateral Dorsolateral Prefrontal Cortex in Patients with Post-Ischemic Stroke Insomnia. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1559-1561.
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2025, Vol. 42 
