Abstract：【Objective】 To explore the correlation between the activity of thrombophilia three indices [protein C(PC), protein S(PS), antithrombin-Ⅲ(AT-Ⅲ)], D-dimer, homocysteine(Hcy) levels in pregnant women and fetal growth restriction(FGR).【Methods】 A total of 38 pregnant women with FGR admitted to our hospital from January 2023 to January 2024 were selected as the FGR group, and 40 healthy pregnant women who delivered in our hospital during the same period were selected as the control group. Enzyme-linked immunosorbent assay(ELISA) was used to detect the activity of thrombophilia three indices, D-dimer, and Hcy levels in both groups. Logistic multivariate regression analysis was used to analyze their correlation with FGR.【Results】 The PC activity and AT-Ⅲ activity in the FGR group were lower than those in the control group, while the levels of D-dimer and Hcy were higher than those in the control group. The fetal tibial length, biparietal diameter, and head circumference in the FGR group were shorter/smaller than those in the control group, with statistically significant differences(P<0.05). Correlation analysis showed that PC activity, AT-Ⅲ activity, D-dimer, and Hcy levels were significantly correlated with FGR(P<0.05). Logistic multivariate regression analysis showed that low PC activity, low AT-Ⅲ activity, high D-dimer level, and high Hcy level were risk factors for FGR in pregnant women(P<0.05).【Conclusion】 Low PC activity, low AT-Ⅲ activity, high D-dimer level, and high Hcy level in pregnant women are significantly correlated with the occurrence of FGR. PC activity, AT-Ⅲ activity, D-dimer, and Hcy can be used as important markers to predict FGR in pregnant women, which is helpful for early diagnosis and prevention of FGR.
2025, Vol. 42 
