床旁纤维支气管镜灌洗术在急性酒精中毒合并吸入性肺炎患者中的应用效果

doi:10.3969/j.issn.1671-7171.2025.08.015

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摘要【目的】探讨床边纤维支气管镜灌洗术在急性酒精中毒合并吸入性肺炎患者中的应用效果。【方法】选取2020年12月至2023年12月本院收治的108例急性酒精中毒合并吸入性肺炎患者,根据患者入院先后顺序分为对照组与观察组,每组54例。对照组实施常规药物治疗,观察组在对照组基础上给予床边纤维支气管镜灌洗术治疗,比较两组治疗前后血清炎症因子水平与氧代谢指标。【结果】治疗后,观察组血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05) 。治疗后,两组氧输送量(DO₂)、氧合指数(PaO₂/FiO₂)、动脉血氧含量(CaO₂)均升高, 氧消耗量(VO₂)、乳酸(Lca)均降低,且观察组优于对照组(P<0.05)。【结论】床边纤维支气管镜灌洗术应用于急性酒精中毒合并吸入性肺炎患者中,可以有效减轻炎症反应,改善患者氧代谢指标。

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	刘源
	马宁

关键词 ：急性酒精中毒, 肺炎,吸入性, 支气管镜检查, 支气管肺泡灌洗

Abstract：【Objective】To explore the application effect of bedside flexible bronchoscope lavage in patients with acute ethanol intoxication complicated by aspiration pneumonia. 【Methods】A total of 108 patients with acute ethanol intoxication complicated by aspiration pneumonia admitted to our hospital from December 2020 to December 2023 were selected. According to the order of admission, they were divided into a control group and an observation group, with 54 cases in each group. The control group received conventional drug treatment, while the observation group was given additional bedside flexible bronchoscope lavage on the basis of the control group. The serum inflammatory factor levels and oxygen metabolism indicators of the two groups before and after treatment were compared. 【Results】After treatment, the levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the observation group were lower than those in the control group (P<0.05). After treatment, in both groups, oxygen delivery (DO₂), oxygenation index (PaO₂/FiO₂), and arterial oxygen content (CaO₂) increased, while oxygen consumption (VO₂) and lactate (Lca) decreased; and the observation group was better than the control group (P<0.05). 【Conclusion】The application of bedside flexible bronchoscope lavage in patients with acute ethanol intoxication complicated by aspiration pneumonia can effectively reduce the inflammatory response and improve the patients' oxygen metabolism indicators.

Key words： Alcoholic Intoxication Pneumonia, Aspiration Bronchoscopy Bronchoalveolar Lavage

收稿日期: 2024-10-16

中图分类号:

R595.6

引用本文:

刘源, 马宁. 床旁纤维支气管镜灌洗术在急性酒精中毒合并吸入性肺炎患者中的应用效果[J]. 医学临床研究, 2025, 42(8): 1347-1349.
LIU Yuan, MA Ning. Application Effect of bedside Flexible Bronchoscope Lavage in Patients with Acute Ethanol Intoxication Complicated by Aspiration Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2025, 42(8): 1347-1349.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.08.015 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I8/1347

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