Abstract：【Objective】To investigate the risk factors of secondary infection in patients with severe acute pancreatitis treated by ultrasound-guided percutaneous catheter drainage (PCD). 【Methods】The clinical data of 70 patients with severe acute pancreatitis treated with ultrasound-guided PCD from January 2021 to January 2024 were retrospectively analyzed, and the patients were divided into infected group (n=28) and uninfected group (n=42) according to whether they had secondary infection. Clinical data of all patients were collected, and clinical data and related laboratory indicators [albumin (ALB), white blood cell (WBC) count, hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT), platelet count (PLT), blood urea nitrogen (BUN)] of the two groups were compared. Multivariate Logistic regression was used to analyze the risk factors of secondary infection in patients with severe acute pancreatitis. 【Results】 The age of the infected group was ≥60 years old, the APACHE Ⅱ score at admission was > 11 points, the mechanical ventilation time was ≥6 days, the proportion of hypoxemia and multiple organ failure was higher than that of the uninfected group, and the WBC, PCT and hs-CRP were higher than that of the uninfected group, with statistical significance (P<0.05). Multivariate Logistic regression analysis showed that increased WBC count, increased hs-CRP, increased PCT, age ≥60 years, APACHE Ⅱ score > 11 points upon admission, mechanical ventilation duration ≥6 days, hypoxemia and multiple organ failure were risk factors for secondary infection in patients with severe acute pancreatitis (P<0.05).【Conclusion】Secondary infection after treatment of severe acute pancreatitis with ultrasound-guided PCD is related to age, APACHE Ⅱ score at admission, mechanical ventilation time, hypoxemia, multiple organ failure and other factors. WBC count, hs-CRP and PCT can be used as predictors of secondary infection of severe acute pancreatitis.
孙向磊, 李娅, 王燕. 超声引导下经皮穿刺置管引流术治疗重症急性胰腺炎患者继发感染的危险因素[J]. 医学临床研究, 2025, 42(3): 463-466.
SUN Xianglei, LI Ya, WANG Yan. Risk Factors of Secondary Infection in Patients with Severe Acute Pancreatitis Treated by Ultrasound-Guided Percutaneous Catheter Drainage. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 463-466.
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2025, Vol. 42 
