Clinical Effect of Valproic Acid Oral Liquid Combined with Levetiracetam Oral Liquid in the Treatment of Children with Epilepsy and its Influence on Cognitive Function
CUI Xiaolin, ZONG Jiwen, WANG Chunxiao
Xinmi Hospital of Traditional Chinese Medicine, Xinmi Henan 452300
Abstract：【Objective】To investigate the clinical effect of valproic acid oral liquid combined with levetiracetam oral liquid in the treatment of children with epilepsy and its influence on cognitive function. 【Methods】A total of 36 children with epilepsy admitted to our hospital from February 2021 to February 2023 were divided into combination group and routine group according to treatment methods, with 18 cases in each group. The conventional group was given valproic acid oral liquid, and the combined group was combined with levetiracetam oral liquid on the basis of the conventional group. Both groups were treated for 6 months. The two groups were compared in terms of the efficacy, clinical symptom improvement (seizure frequency, seizure duration) and cognitive function [verbal intelligence quotient (VIQ), operational intelligence quotient (PIQ), full scale intelligence quotient (FIQ)], neurotransmitter [S-100β protein, high mobility group protein-1 (HMGB-1), neuropeptide Y (NPY), galanin (GAL)] and incidence of adverse reactions. 【Results】The total effective rate of the combined group was higher than that of the conventional group, the difference was statistically significant (P<0.05). After treatment, the seizure frequency of the two groups was lower than before treatment, and the seizure time was shorter than before treatment, and the seizure frequency of the combined group was lower than that of the conventional group, and the seizure time was shorter than that of the conventional group, with statistical significance (P<0.05). After treatment, VIQ, PIQ and FIQ scores in 2 groups were higher than before treatment, and the combined group was higher than the conventional group (P<0.05). After treatment, the levels of serum S-100β protein and HMGB-1 were lower than before treatment, and the levels of serum NPY and GAL were higher than before treatment, and the difference was statistically significant between the combined group and the conventional group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Valproic acid oral liquid combined with levetiracetam oral liquid is effective in the treatment of children with epilepsy, which can effectively reduce the frequency and duration of seizures and reduce the damage to cognitive function of children.
崔晓琳, 宗继文, 王春晓. 丙戊酸口服液联合左乙拉西坦口服液治疗儿童癫痫的临床效果及对患儿认知功能的影响[J]. 医学临床研究, 2025, 42(1): 112-115.
CUI Xiaolin, ZONG Jiwen, WANG Chunxiao. Clinical Effect of Valproic Acid Oral Liquid Combined with Levetiracetam Oral Liquid in the Treatment of Children with Epilepsy and its Influence on Cognitive Function. JOURNAL OF CLINICAL RESEARCH, 2025, 42(1): 112-115.
[1] CERULLI IRELLI E,LEODORI G,MORANO A, et al. EEG markers of treatment resistance in idiopathic generalized epilepsy from standard EEG Findings to advanced signal analysis[J].Biomedicines,2022,10(10):2428. [2] 房海波,王荣,褚琳娜,等.伴中央颞区棘波的儿童良性癫痫共患注意缺陷多动障碍患儿认知功能损害的前瞻性研究[J].中国当代儿科杂志,2021,23(8):791-796. [3] 张小龙,张远达,何华芬,等.丙戊酸、奥卡西平、左乙拉西坦单药治疗对学龄期癫痫患儿的疗效及骨代谢水平影响[J].中国儿童保健杂志,2020,28(3):331-334. [4] 张晓青,孙素真,唐洪侠,等.托吡酯联合左乙拉西坦对难治性癫痫患儿脑电活动、免疫球蛋白和生活质量的影响[J].现代生物医学进展,2020,20(18):3537-3540. [5] 吴海威,张娜.左乙拉西坦联合丙戊酸钠治疗癫痫的效果及对脑损伤标志物和炎症因子的影响[J].河北医药,2021,43(10):1535-1537. [6] GLAUSER T, BEN-MENACHEM E, BOURGEOIS B, et al.ILAE treatment guidelines evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes[J].Epilepsia,2006,47(7):1094-1120. [7] CARTER B,COOK G,BRAY L,et al.Parents/caregivers fears and concerns about their child's epilepsy A scoping review[J].PLoS One,2022,17(9):e0274001. [8] BRIGO F,IGWE S C,LATTANZI S,et al.Ethosuximide sodium valproate or lamotrigine for absence seizures in children and adolescents[J].Cochrane Database Syst Rev,2003(3):CD003032. [9] 李立佳,邹琴,阎青青,等.左乙拉西坦与丙戊酸钠治疗儿童枕叶癫痫睡眠中癫痫性电持续状态的疗效及对认知功能的影响比较[J].儿科药学杂志,2021,27(6):1-4. [10] 陈书远,刘金宝,刘世祺,等.左乙拉西坦联合奥卡西平治疗儿童癫痫的疗效及对患者免疫功能、脑电图及认知功能的影响[J].海南医学,2022,33(7):894-897. [11] 张云茜,简秀群,许虹,等.伴中央颞区棘波的儿童良性癫痫患儿认知功能障碍影响因素的研究进展[J].中华神经科杂志,2021,54(7):712-717. [12] 张金来,曹月荣,于洁,等.维生素E辅助拉莫三嗪治疗癫痫患儿的临床效果及对血清神经肽Y、胰岛素样生长因子-1、脑源性神经营养因子和S100B蛋白水平的影响[J].广西医学,2020,42(16):2076-2079. [13] 李学广,苏志恒,梁其跃,等.癫痫患儿血清同型半胱氨酸、S100B蛋白、NPY水平与预后的相关性分析[J].中国实验诊断学,2020,24(9):1515-1517. [14] 李国钦,陈玉明,蒋时笑,等.血清NSE、NPY及GAL水平与成人癫痫持续状态的关系及临床意义[J].中华保健医学杂志,2020,22(4):435-437. [15] 阮卫云,李卫征,郭燕燕,等.脑电图联合血清神经元特异性烯醇化酶、胶质纤维蛋白和S-100β对癫痫病情评估的意义[J].中华生物医学工程杂志,2021,27(2):198-200.
2025, Vol. 42 
