Abstract：【Objective】To analyze the potential causal relationship between sarcopenia and gastric cancer at the genetic level using two sample bidirectional Mendelian randomization(MR).【Methods】Significant instrumental variables(IV) were obtained from publicly available genome-wide association studies(GWAS) statistical data for two sample MR analysis. Sensitivity analysis was performed using methods such as Cochran's Q test to ensure that IV met the three major hypotheses. Methods such as inverse variance weighting(IVW) were used to evaluate the bidirectional causal relationship between gastric cancer and sarcopenia.【Results】The positive MR analysis results showed that no causal relationship was found between gastric cancer and limb muscle mass(ALM)(OR=-0.019, P=0.446), left hand grip strength(OR=-0.008, P=0.059), and right hand grip strength(OR=-0.010, P=0.220)(P>0.05); No causal relationship was found between the above indicators in the reverse MR analysis(P>0.05).【Conclusion】There is no direct causal relationship between gastric cancer and sarcopenia at the genetic level.
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2024, Vol. 41 
