宫腹腔镜联合药物促排卵治疗输卵管性不孕患者的临床效果<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.06.005

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摘要【目的】探讨宫腹腔镜联合药物促排卵治疗输卵管性不孕患者的临床效果。【方法】选取本院诊治的60例输卵管性不孕患者作为研究对象,按照随机数字表法分为A组(采用宫腹腔镜联合尿促卵泡素治疗)、B组(采用宫腹腔镜联合来曲唑治疗)和C组(采用宫腹腔镜治疗),每组20例。比较两组患者卵巢功能指标、术后受孕时间、妊娠率、流产率、分娩率、畸形胎儿率。【结果】A组、B组、C组治疗后卵巢功能指标雌二醇(E₂)、卵泡刺激素(FSH)、促黄体生成素(LH)水平均高于治疗前(P<0.05);A组治疗后LH、FSH、E₂水平显著高于B组和C组(P<0.05);B组治疗后LH、FSH、E₂水平显著高于C组(P<0.05)。A组、B组、C组妊娠率分别为85.00%、75.00%、55.00%,三组比较,差异有统计学意义(P<0.05)。A组术后受孕时间均短于B组、C组(P<0.05);B组术后受孕时间短于C组(P<0.05)。A组、B组、C组流产率分别为5.88%、6.67%、27.27%,三组比较,差异有统计学意义(P<0.05);A组、B组、C组分娩率分别为94.12%、93.33%、72.73%,三组比较,差异有统计学意义(P<0.05);A组、B组、C组畸形胎儿率分别为0、0、9.09%,三组比较,差异无统计学意义(P>0.05)。【结论】宫腹腔镜联合药物促排卵治疗输卵管性不孕患者,可有效改善卵巢功能,提高妊娠率、分娩率,降低流产率,但相对于来曲唑治疗,宫腹腔镜联合尿促卵泡素治疗方案效果更佳,值得临床推广应用。

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关键词 ：不育, 女(雌)性/治疗, 输卵管疾病/治疗, 宫腔镜检查, 治疗结果

Abstract：【Objective】To explore the clinical effect of hysterolaparoscopy combined with medication for ovulation induction in the treatment of patients with tubal infertility. 【Methods】 Sixty patients with tubal infertility treated in our hospital were selected as the study subjects. They were randomly divided into Group A(treated with hysterolaparoscopy combined with Urofollitrophin), Group B(treated with hysterolaparoscopy combined with letrozole), and Group C(treated with hysteroscopy) using a random number table method, with 20 cases in each group. Two groups of patients were compared in terms of ovarian function indicators, postoperative pregnancy time, pregnancy rate, miscarriage rate, delivery rate, and abnormal fetal rate.【Results】 After treatment, the levels of ovarian function indicators such as estradiol(E₂), follicle stimulating hormone(FSH), and luteinizing hormone(LH) in groups A, B, and C were higher than before treatment(P<0.05); After treatment, the levels of LH, FSH, and E₂ in Group A were significantly higher than those in Group B and Group C(P<0.05); After treatment, the levels of LH, FSH, and E₂ in Group B were significantly higher than those in Group C(P<0.05). The pregnancy rates of Group A, Group B, and Group C were 85.00%, 75.00%, and 55.00%, respectively. The differences among the three groups were statistically significant(P<0.05). The postoperative conception time in Group A was shorter than that in Group B and Group C(P<0.05); The postoperative conception time in Group B was shorter than that in Group C(P<0.05). The abortion rates of Group A, Group B, and Group C were 5.88%, 6.67%, and 27.27%, respectively. The difference among the three groups was statistically significant(P<0.05); The delivery rates of Group A, Group B, and Group C were 94.12%, 93.33%, and 72.73%, respectively. The differences among the three groups were statistically significant(P<0.05); The rates of abnormal fetuses in Group A, Group B, and Group C were 0, 0, and 9.09%, respectively. There was no statistically significant difference among the three groups(P>0.05).【Conclusion】 The combination of Hysterolaparoscopy and medication for ovulation induction can effectively improve ovarian function, increase pregnancy and delivery rates, and reduce miscarriage rates in patients with tubal infertility. However, compared to letrozole treatment, the combination of hysteroscopy and urinary follicle stimulating hormone treatment is more effective and worthy of clinical promotion and application.

Key words： Infertility, Female/TH Fallopian Tube Diseases/TH Hysteroscopy Treatment Outcome

收稿日期: 2024-03-22

中图分类号:

R711.75

基金资助:^*上海市金山区医药卫生科技创新项目(编号:2022-WS-18)

通讯作者: ^**E-mail:maobaoyun001@126.com

引用本文:

孙海云, 赵通, 胡玉宏, 孟缓缓, 唐琳, 毛宝红. 宫腹腔镜联合药物促排卵治疗输卵管性不孕患者的临床效果^*[J]. 医学临床研究, 2024, 41(6): 817-819.
SUN Haiyun, ZHAO Tong, HU Yuhong,et al. Clinical Efficacy of Hysterolaparoscopy Combined with Medication for Ovulation Induction in the Treatment of Tubal Infertility Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 817-819.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.06.005 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I6/817

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