Expression Levels of IFN-γ and IL-4 in Serum of Patients with Acute Traumatic Spinal Cord Injury Complicated with Infection and their Clinical Significance
LI Wang, LI Jiaping
Department of Emergency, Xi'an People's Hospital (The Fourth Hospital of Xi'an), Xi'an Shaanxi 710000
Abstract：【Objective】To investigate the expression levels and clinical significance of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in the serum of patients with acute traumatic spinal cord injury complicated with infection. 【Methods】A retrospective analysis was conducted on 86 patients with acute traumatic spinal cord injury treated in our hospital from February 2017 to February 2022. The patients were divided into infection group (n=26) and non-infection group (n=60). The basic information and levels of IFN-γ and IL-4 were compared between the two groups. Multivariate Logistic regression was used to analyze the factors affecting post-injury infection in patients with acute traumatic spinal cord injury. The predictive value of IL-4 and IFN-γ for post-injury infection was analyzed using the receiver operating characteristic (ROC) curve. 【Results】The proportion of patients aged ≥60 years, ASIA (American Spinal Injury Association) score indicating complete injury, time from injury to admission ≥48 hours, and not using prophylactic antibiotics was higher in the infection group. IL-4 levels were higher and IFN-γ levels were lower in the infection group compared to the non-infection group (P<0.05). ROC curve analysis confirmed that IL-4 and IFN-γ can be used to predict post-injury infection in patients with acute traumatic spinal cord injury, with area under the curve (AUC) values of 0.875 and 0.906. Logistic regression analysis showed that age ≥60 years, ASIA score indicating complete injury, time from injury to admission ≥48 hours, not using prophylactic antibiotics, IFN-γ ≤14.084 pg/mL, and IL-4 ≥79.711 pg/mL were risk factors for post-injury infection in patients with acute traumatic spinal cord injury (P<0.05). 【Conclusion】The levels of IL-4 and IFN-γ are significantly correlated with the occurrence of post-injury infection in patients with acute traumatic spinal cord injury. Dynamic monitoring of IL-4 and IFN-γ levels can help assess the risk of post-injury infection complications.
李旺, 李佳平. IFN-γ、IL-4在急性创伤性脊髓损伤合并感染患者血清中的表达水平及其临床意义[J]. 医学临床研究, 2023, 40(10): 1508-1511.
LI Wang, LI Jiaping. Expression Levels of IFN-γ and IL-4 in Serum of Patients with Acute Traumatic Spinal Cord Injury Complicated with Infection and their Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2023, 40(10): 1508-1511.
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2023, Vol. 40 
