Abstract：【Objective】 To investigate the clinical efficacy of programmed death protein 1 (PD-1) monoclonal antibody combined with microwave ablation in the treatment of primary liver cancer. 【Methods】 The clinical data of 78 patients with primary liver cancer admitted to our hospital from January 2019 to October 2020 were analyzed retrospectively. According to the different treatment methods, they were divided into combined group (treated with PD-1 monoclonal antibody combined with microwave ablation) and control group (treated with single microwave ablation), with 39 patients in each group. The clinical efficacy, immune function and adverse reactions of the two groups were compared, and the survival rate was analyzed by Kaplan-Meier. 【Results】 The disease control rate and objective remission rate in the combined group were higher than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of CD39+ and CD73+ in both groups were lower than those before treatment, and those in the combined group were lower than those in the control group (P<0.05). The incidence of rash in the combined group was higher than that in the control group (P<0.05); There was no statistically significant difference in the occurrence of other adverse reactions between the two groups(P>0.05). The difference between the two groups was statistically significant (P<0.05). 【Conclusion】 PD-1 monoclonal antibody combined with microwave thermal ablation is helpful to improve the disease control rate and prolong the survival time of patients with primary liver cancer, and has certain safety.
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2023, Vol. 40 
