Abstract：【Objective】To investigate the effect of lactitol powder combined with Xuebijing injection in the treatment of bacterial peritonitis and its influence on inflammatory mediators, total bilirubin (TBIL) and prostaglandin E2 (PGE2). 【Methods】A total of 88 patients with bacterial peritonitis admitted to our hospital from March 2018 to April 2020 were selected and divided into two groups by random number table, with 44 cases in each group. On the basis of conventional treatment, the control group was given lactitol powder, and the observation group was given lactitol powder combined with Xuebijing injection. The efficacy and the recovery time of clinical symptoms and signs after 2 courses of treatment, liver function indexes [serum alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (Alb), aspartate aminotransferase (AST)], serum PGE2, pre-granulin (PGRN) before treatment, after treatment and adverse reactions were compared between the two groups. 【Results】The total effective rate (88.64%) of the observation group after 2 courses of treatment was higher than that of the control group (70.45%) (P<0.05). The time of body temperature returning to normal, the time of abdominal pain disappearing, the time of stopping diarrhea, the time of abdominal tenderness disappearing, and the negative time of ascites culture in the observation group were shorter than those in the control group (P<0.05). After 1 and 2 courses of treatment in the observation group, ALT, TBIL and AST were lower than the control group, and Alb was higher than the control group (P<0.05). After 2 courses of treatment in the observation group, PGE2 was higher than the control group, and PGRN was lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was 2.27% (1/44), compared with 6.82% (3/44) in the control group, there was no statistically significant difference (P>0.05). 【Conclusion】Lactitol powder combined with Xuebijing injection in the treatment of bacterial peritonitis can speed up the recovery of clinical symptoms and signs, improve liver function. It has a significant effect and high safety.
管敏, 王勇, 李汝东. 拉克替醇散联合血必净注射液治疗自发性细菌性腹膜炎的效果及对血清PGE2、PGRN水平的影响[J]. 医学临床研究, 2021, 38(1): 110-113.
GUAN Min, WANG Yong, LI Ru-dong. Effect of Lactitol Powder and Xuebijing Injection on Bacterial Peritonitis and Its Influence on PGRN and PGE2. JOURNAL OF CLINICAL RESEARCH, 2021, 38(1): 110-113.
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2021, Vol. 38 
