Abstract：【Objective】To observe the effect of ulinastatin injection on inflammatory reaction of abdominal surgery in the perioperative period and its effect on renal functions.【Methods】One hundred and eight patients undergoing abdominal surgery were randomly divided into control group (n=90) and observation group (n=90). The control group received intravenous drip of Glucose Injection in the perioperative period, and the observation group was given intravenous drip of Ulinastatin Injection. The changes of inflammatory factors, renal function indexes and postoperative complications were compared between the two groups.【Results】Before operation, there was no significant difference in the two groups in the levels of inflammatory factors such as interferon-β (IFN-β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as renal function, blood urea nitrogen, uric acid and creatinine levels (P>0.05);The levels of inflammatory factors, blood urea nitrogen, uric acid and creatinine in the observation group were significantly lower than those in the control group, and the difference was significant (P<0.05);The postoperative complication rate of the observation group was 4.44% (4/90), which was lower than that of the control group 11.11% (10/90), and the difference between the two groups was significant (P<0.05).【Conclusion】Ulinastatin injection is ideal for patients undergoing abdominal surgery. It can reduce the inflammatory response and improve the renal function of patients.
舒远富. 乌司他丁对腹部手术患者围术期炎症反应及肾功能的影响[J]. 医学临床研究, 2018, 35(2): 249-251.
SHU Yuan-fu. Effect of Ulinastatin on Inflammatory Response and Renal Function in Patients Undergoing Abdominal Surgery. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 249-251.
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2018, Vol. 35 
