Abstract:To explore the value of low concentration iodine contrast medium combined with low voltage in prospective ECG-trigger gated coronary artery CT angiography (CTA) .[Methods] Totally 59 patients [body mass index(BMI)<24 kg/m2 ] suspected as coronary heart disease were collected continuously and divided into 3 groups randomly .Group A( n=25) and group B( n=14) received 270 mgI/mL and 320 mgI/mL contrast medium and 80 kV and 100 kV tube voltage respectively ,while group C( n = 20) received 370mgI/mL contrast medium and 120 kV tube voltage . Prospective ECG-trigger sequence scan was performed in all patients of 3 groups .The effective radiation dose(ED) was recorded .Mean CT value of aorta root was measured .CTA image quality of all patients was scored .[Results] The ED in group A ,B and C were (2 .00 ± 0 .56) ,(2 .51 ± 0 .52) and (4 .17 ± 1 .55)mSv respectively ,and there were significant differences among 3 groups( P <0 .05) .The enhanced degree of aortic root in group A ,B and C were (486 .8 ± 113 .98) ,(407 .43 ± 83 .63) and (439 .73 ± 72 .12)HU re-spectively ,and there was significant difference only between group A and group B ( t =2 .28 ,P <0 .05) .Group A ,B and C showed 225 ,126 and 126 coronary segments ,respectively .The excellent rate of group A ,B and C were 94 .67% ,89 .68% and 94 .67% respectively ,and there was significant difference between group B and C (χ2= 4 .00 ,P<0 .05) ,but there was no significant difference between group A and group B or between group A and group C(χ2 = 4 .00 and 0 .17 ,all P >0 .05) .[Conclusion] Low concentration iodine contrast medium combined with low tube voltage in coronary artery CTA scan for standard and low body weight people can obtain satisfactory diagnosis image quality and reduce injection dose and ED of iodine obviously .