Abstract：【Objective】 To investigate the effect of transcatheter arterial chemoembolization (TACE) combined with apatinib or Solafinib on alpha-fetoprotein (AFP) in patients with Hepatocellular Carcinoma (HCC). 【Methods】 A total of 60 patients with HCC admitted to our hospital from July 2015 to April 2019 were randomly divided into two groups. The solafinib group (n=30) was treated with TACE combined with solafinib, while the apatinib group was treated with TACE combined with apatinib. The clinical efficacy of the two groups was analyzed. 【Results】 There was no significant difference in objective remission rate between the apatinib group (56.67%) and the solafinil group (53.33%) (P>0.05).The levels of AFP, heat shock protein 90 α (Hsp90 α) and vascular endothelial growth factor (VEGF) between the two groups before treatment were not significantly different (P>0.05). After treatment, the levels of AFP,Hsp90 α and VEGF in the two groups were lower than those before treatment (P<0.05). However, there was no significant difference in the levels of AFP, Hsp90 α and VEGF between the apatinib group and the solafinil group after treatment (P>0.05). No patients had grade Ⅳ adverse reactions in both groups. The incidence of skin and mucous membrane reaction (73.33%) and hypertension (56.67%) in the apatinib group were higher than those in the solafinil group. The incidence of bone marrow suppression (46.67%) and gastrointestinal reaction (53.33%) of the apatinib group were not significantly different from those of the solafinil group (P>0.05). 【Conclusion】 After TACE, the efficacy of apatinib or solafinib in the treatment of HCC is similar showing that the expression of AFP,Hsp90α and VEGF was decreased, however, the safety of solafinib was relatively higher than that of apatinib.
陈秀峰. 经皮肝动脉化疗栓塞术后联合阿帕替尼或索拉非尼对原发性肝癌患者甲胎蛋白的影响[J]. 医学临床研究, 2020, 37(4): 551-553.
CHEN Xiu-feng. Effect of TACE Combined with Apatinib or Solafinib on Alpha-fetoprotein in Patients with Hepatocellular Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2020, 37(4): 551-553.
2020, Vol. 37 
