Abstract:【Objective】To in vestigate the expression and significance of Livin protein and PTEN protein in endometriosis (EMs) tissues. 【Methods】From January 2016 to may 2018, 80 cases of postoperative EMs endometrial tissue (EMs group) and 80 cases of normal endometrial tissue obtained from hysteromyoma operation were selected as the control group. Livin and PTEN protein levels in the two groups were detected and compared by immunohistochemistry, and their clinical significance was analyzed.【Results】The positive expression rate of PTEN protein in the EMs group was significantly lower than that in the control group (P<0.05) positive expression rate of Livin protein was significantly higher than that in control group (P<0.05); the positive expression rate of Livin protein and PTEN protein in patients with stage Ⅲ~Ⅳ of AFS stage was not significantly different from that of stage Ⅰ~Ⅱ(P>0.05); the positive expression rate of PTEN protein was higher than that of ectopic intima (P<0.05) in EMs patients, and the positive expression rate of Livin protein was lower than that of ectopic intima (P<0.05). 【Conclusion】High expression of Livin protein and low expression of PTEN protein in EMs endometrial tissue may be related to the occurrence of EMs.
储巧香. Livin、PTEN蛋白在EMs组织中的表达及其意义[J]. 医学临床研究, 2020, 37(3): 406-408.
CHU Qiao-xiang. Expression and Significance of Livin and PTEN Proteins in EMs. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 406-408.
[1] Mishra VV. Prevalence; characteristics and management of endometriosis amongst infertile women: a one year retrospective study[J].J Clin Diagn Res,2015,34(6):78-82. [2] Mishra VV, Bandwal P, Agarwal R, et al. Prevalence, clinical and laparoscopic features of endometriosis among infertile women[J].J Obstet Gynaecol India,2017,67(3):208-212. [3] 徐建波,尹香花,苏悦,等. 卵巢子宫内膜异位囊肿恶变危险因素回顾性分析[J].中华肿瘤防治杂志,2017,24(17):1237-1239. [4] 朱巧英,贾雪梅,陈玲,等. 抑癌基因PTEN对人原代子宫内膜细胞凋亡及细胞周期的影响[J].南京医科大学学报(自然科学版),2015,35(11):1533-1537. [5] 祝平,沈树娜. 子宫内膜异位症中Livin和Smac的表达及相关性研究[J].中国妇幼健康研究,2016,27(4):466-469. [6] 中华医学会妇产科学分会子宫内膜异位症协作组. 子宫内膜异位症的诊治指南 [J].中华妇产科杂志,2015,50(3):161-169. [7] Morassutto C, Monasta L, Ricci G, et al. Incidence and estimated prevalence of endometriosis and adenomyosis in northeast italy: a data linkage study[J].PLoS One,2016,11(4):227-229. [8] Reid R, Steel A, Wardle J, et al. The prevalence of self-reported diagnosed endometriosis in the Australian population: results from a nationally-representative survey[J].BMC Res Notes,2019,12(1):45-47. [9] Yamamoto A, Johnstone EB, Bloom MS, et al. A higher prevalence of endometriosis among Asian women does not contribute to poorer IVF outcomes[J].J Assist Reprod Genet,2017,34(6):765-774. [10] 董立娜,贾桂芝. 子宫内膜异位症患者术后复发的影响因素分析[J].中国计划生育和妇产科,2018,10(6):38-41. [11] 夏伟兰,郭宽萍,陈超,等. DJ-1和PTEN在子宫内膜异位症中的表达及其相关性[J].中国妇幼保健,2017,32(17):4042-4045. [12] 范小华,程文俊. 不同卵巢癌HOXA-10和PTEN及p53的特异性表达差异及意义[J].中华肿瘤防治杂志,2015,22(22):44-45. [13] 王春梅,李洁,孙文萍,等. 人脐带间充质干细胞对异位子宫内膜细胞增殖及凋亡的影响[J].中国组织工程研究,2015,19(41):6628-6632. [14] 刘星娅,王红静,徐盼,等. Livin和PTEN在卵巢子宫内膜异位症癌变组织中的表达和相关性研究[J]. 四川大学学报(医学版),2016,47(4):512-515. [15] 文晓凤,郑洁. 子宫内膜异位症患者内膜组织Livin、半胱氨酸蛋白酶激活剂及Bcl-2蛋白的表达及意义[J].中国妇幼保健,2018,33(4):894-898.