医学临床研究
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医学临床研究  2020, Vol. 37 Issue (3): 406-408    DOI: 10.3969/j.issn.1671-7171.2020.03.026
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Livin、PTEN蛋白在EMs组织中的表达及其意义
储巧香
江苏省海安市人民医院妇产科,江苏 海安 226600
Expression and Significance of Livin and PTEN Proteins in EMs
CHU Qiao-xiang
Department of Obstetrics and Gynecology, Hai'an People's Hospital, Hai'an, Jiangsu 226600
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摘要 【目的】探讨Livin蛋白、PTEN蛋白在子宫内膜异位症(EMs)组织中的表达及其意义。【方法】选取2016年1月至2018年5月在本院病理科获取的术后EMs子宫内膜组织80例(EMs组)和因子宫肌瘤手术获得正常子宫内膜组织80例作为对照组,采用免疫组化法检测并比较两组标本中的Livin、PTEN蛋白表达水平,并分析其临床意义。【结果】EMs组的PTEN蛋白阳性表达率显著低于对照组(P<0.05); Livin蛋白阳性表达率显著高于对照组(P<0.05);AFS分期 Ⅲ~Ⅳ期的EMs组患者Livin蛋白、PTEN蛋白阳性表达率与Ⅰ~Ⅱ期比较差异无统计学意义(P>0.05);EMs患者在位内膜的PTEN蛋白阳性表达率高于异位内膜(P<0.05),在位内膜的Livin蛋白阳性表达率低于异位内膜(P<0.05)。【结论】EMs子宫内膜组织中Livin蛋白高表达、PTEN蛋白低表达,可能与EMs的发生有关。
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储巧香
关键词 子宫内膜异位症基因 抑制 肿瘤    
Abstract:【Objective】To in vestigate the expression and significance of Livin protein and PTEN protein in endometriosis (EMs) tissues. 【Methods】From January 2016 to may 2018, 80 cases of postoperative EMs endometrial tissue (EMs group) and 80 cases of normal endometrial tissue obtained from hysteromyoma operation were selected as the control group. Livin and PTEN protein levels in the two groups were detected and compared by immunohistochemistry, and their clinical significance was analyzed.【Results】The positive expression rate of PTEN protein in the EMs group was significantly lower than that in the control group (P<0.05) positive expression rate of Livin protein was significantly higher than that in control group (P<0.05); the positive expression rate of Livin protein and PTEN protein in patients with stage Ⅲ~Ⅳ of AFS stage was not significantly different from that of stage Ⅰ~Ⅱ(P>0.05); the positive expression rate of PTEN protein was higher than that of ectopic intima (P<0.05) in EMs patients, and the positive expression rate of Livin protein was lower than that of ectopic intima (P<0.05). 【Conclusion】High expression of Livin protein and low expression of PTEN protein in EMs endometrial tissue may be related to the occurrence of EMs.
Key wordsEndometriosis    Genes    Tumor    Suppressor
收稿日期: 2019-09-10     
PACS:  R711.71  
引用本文:   
储巧香. Livin、PTEN蛋白在EMs组织中的表达及其意义[J]. 医学临床研究, 2020, 37(3): 406-408.
CHU Qiao-xiang. Expression and Significance of Livin and PTEN Proteins in EMs. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 406-408.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.03.026     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I3/406
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