医学临床研究
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医学临床研究  2020, Vol. 37 Issue (3): 375-377    DOI: 10.3969/j.issn.1671-7171.2020.03.016
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胸腔镜单孔和三孔肺段切除对早期NSCLC的疗效及IL-8、Fractalkine、MIP-3α的影响
程明, 施卫东, 董汉宣, 于志俊, 张杰
江苏省南通市第二人民医院胸外科,江苏 南通 226002
Effect of Thoracoscopic Single-hole and Three-hole Pneumonectomy on IL-8, Fractalkine and MIP-3α in Patients with Early Non-small Cell Lung Cancer
CHENG Ming, SHI Wei-dong, DONG Han-xuan, et al
Thoracic Surgery Nantong Second People's Hospital Nantong, Jiangsu Province 226002
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摘要 【目的】观察胸腔镜单孔和三孔肺段切除术对早期非小细胞肺癌(NSCLC)的治疗效果,及对患者白介素-8(IL-8)、不规则趋化因子(Fractalkine)、人巨噬细胞炎性蛋白3α(MIP-3α)水平的影响。【方法】选择在本院接受胸腔镜肺段切除术治疗的早期NSCLC患者80例,根据其手术方式分为单孔手术组和三孔手术组。观察两组手术一般情况,比较两组手术前后肺功能、IL-8、Fractalkine、MIP-3α、术后恢复和术后1年生存率的差异。【结果】单孔手术组患者的术中出血量,术后下床活动时间低于三孔手术组(P<0.05),两组患者手术时间、清扫淋巴结数目、术后拔除胸腔引流管时间相比较差异无显著性(P>0.05);两组手术前IL-8、Fractalkine、MIP-3α水平比较差异无显著性(P>0.05);术后单孔手术组患者IL-8、Fractalkine、MIP-3α水平低于三孔手术组,且差异有显著性(P<0.05);两组患者手术前后肺功能相关指标第1秒用力呼气流量(FEV1)、用力肺活量(FVC)、最大自主通气量(MVV)水平相比较差异无显著性(P>0.05);两组患者1年生存率分别为75.00%(30/40)和72.50%(29/40),其差异无显著性(P>0.05);两组患者术后发生肺部感染、神经损伤和胸部疼痛的比例相比较差异无显著性(P>0.05)。【结论】胸腔镜单孔和三孔肺段切除术对早期NSCLC的疗效相当,但单孔手术创伤小,对IL-8、Fractalkine、MIP-3α水平改善效果好,具有良好的应用价值。
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关键词 非小细胞肺/外科学白细胞介素    
Abstract:【Objective】To investigate the efficacy of thoracoscopic single-hole and three-hole pneumonectomy in patients with early non-small cell lung cancer (NSCLC) and their effects on interleukin-8 (IL-8), irregular chemokines (Fractalkine) and human macrophage inflammatory protein 3α (MIP-3α) levels. 【Methods】Patients with early non-small cell lung cancer who underwent thoracoscopic pneumonectomy at our hospital were selected. The surgical methods were thoracoscopic single-hole and three-hole pneumonectomy. The general surgical information, lung function, IL-8, Fractalkine, MIP-3α, postoperative recovery and 1-year survival rate were compared between the two groups. 【Results】 The intraoperative blood loss and the time to get out of bed after operation in patients of the single-hole operation group were lower than those of the three-hole operation group (P<0.05). There were no significant differences in the operation time, number of lymph nodes dissipated, and time to remove the thoracic drainage tube between the two groups (P>0.05). Levels of IL-8, Fractalkine and MIP-3α before surgery did not show significant differences between the two groups (P>0.05). After surgery, the levels of IL-8, Fractalkine, and MIP-3α in the single-hole operation group level was lower than those in the three-hole operation group; and the differences were statistically significant (P<0.05). There were no significant differences of lung function-related indicators: forced expiratory velocity at the first second (FEV1), forced vital capacity (FVC), and maximum voluntary ventilation (MVV) levels before and after surgery between the two groups of patients (P>0.05). The one-year survival rates of the two groups were 75.00% and 72.50%, respectively, which had no significant difference (P<0.05). The number of postoperative lung infections, nerve injuries and chest pain in the two groups were no significant difference as well (P>0.05). 【Conclusion】Thoracoscopic single-hole and three-hole pneumonectomy are similarly effective for patients with early non-small cell lung cancer. However, single-hole surgery has less trauma and can lower levels of IL-8, Fractalkine and MIP-3α, which has good application value.
Key wordsCancer    Non-Small Cell Lung Cancer    Interleukin
收稿日期: 2019-05-10     
PACS:  R734.2  
引用本文:   
程明, 施卫东, 董汉宣, 于志俊, 张杰. 胸腔镜单孔和三孔肺段切除对早期NSCLC的疗效及IL-8、Fractalkine、MIP-3α的影响[J]. 医学临床研究, 2020, 37(3): 375-377.
CHENG Ming, SHI Wei-dong, DONG Han-xuan, et al. Effect of Thoracoscopic Single-hole and Three-hole Pneumonectomy on IL-8, Fractalkine and MIP-3α in Patients with Early Non-small Cell Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(3): 375-377.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.03.016     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I3/375
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