Abstract:【Objective】To investigate the clinical effect of transvaginal sacrospinous ligament suspension and pelvic funnel ligament suspension in the treatment of pelvic organ prolapse.【Methods】A total of 47 patients with pelvic organ prolapse (POP) treated in our hospital from January 2016 to November 2018 were selected and divided into the observation group (n=27) and the control group (n=20) according to the selected surgical scheme. Patients in the observation group were treated with vaginal sacrospinous ligament suspension, while patients in the control group were treated with pelvic funnel ligament suspension. The operation time and bleeding volume were recorded. All patients underwent POP-Q measurement at 3 months after operation. In the measurement, Ba referred to the anterior wall of the vagina at a distance of 3 cm from the edge of the hymen, C referred to the stump of the vagina and Bp referred to the reflex of the vaginal fornix and the stump of the vagina to the midline of the vaginal hymen. The pelvic floor dysfunction questionnaire-20 (PFDI-20) and the pelvic organ prolapse/urinary incontinence sexual questionnaire-12 (PISQ-12) were used to evaluate the quality of life and sexual life of patients.【Results】The operation time, intraoperative bleeding volume and indwelling time of urinary catheter in the observation group were (64.02±13.22) min, (87.20±12.23) ml and (87.92 ±12.21) h, irrespectively, which were significantly shorter than those in the control group (P<0.05). Ba, C, and Bp in the observation group and the control group were improved at 3 months after surgery (P<0.05), however, there was no significant difference in Ba, C, and Bp at 3 months after surgery in the two groups (P> 0.05). One year after operation, the PDFI-20 score of the observation group was (20.03±2.19), which was significantly lower than that of the control group (P<0.05); while the PISQ-12 score was (43.30±5.10), which was significantly higher than that of the control group (P<0.05). There was no significant difference in the incidence of complications between the observation group and the control group (P>0.05); No recurrence occurred during the follow-up period in the observation group and the control group.【Conclusion】Transvaginal sacrospinous ligament suspension has significant curative effect on pelvic organ prolapse. It can reduce the operation time and the amount of intraoperative bleeding, and improve the quality of patients' lives and sexual life, which is worthy of clinical promotion and application.