Abstract：【Objective】To explore the clinical effect of tamoxifen combined with gestrinone in the prevention of postoperative recurrence of endometriosis.【Methods】From January 2016 to January 2017, 86 patients with endometriosis who were treated in Taikang Xianlin Gulou Hospital and Huaiyin Hospital of Huai'an City, Jiangsu Province were randomly divided into the observation group and the control group according to the random number table method. The control group was treated with gestrinone, and the observation group was treated with tamoxifen on the basis of the control group. The clinical effect, immune function, estrogen (E2) and follicle stimulating hormone (FSH) were compared between the two groups. 【Results】The total effective rate of the observation group was significantly higher than that of the control group (97.7% vs 83.7%), and the recurrence rate was lower than that of the control group (2.32% vs 16.28%). The difference was statistically significant [χ2 (effective)=5.109,P=0.024;χ2(recurrence) = 4.962, P=0.026]. Before treatment, there was no significant difference in immune function indexes and hormone levels between the two groups (P> 0.05); after treatment, the levels of CD4+ CD8+ CD4+/CD8+ in the two groups were increased, and the increase was more obvious in the observation group (P<0.05); the levels of E2 and FSH were decreased, and the decrease was more obvious in the observation group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 2.3% (1/43), which was significantly lower than that in the control group 20.9% (9/43), and the difference was statistically significant (P<0.05).【Conclusion】Tamoxifen combined with gestrinone can prevent the recurrence of endometriosis after operation. It has a significant effect, improves the immune function and hormone level of patients, and has a high safety. It is worthy of clinical application.
姚晶, 孙静, 刘素芹. 他莫西芬联合孕三烯酮预防子宫内膜异位症术后复发的疗效观察[J]. 医学临床研究, 2020, 37(1): 36-38.
YAO Jing, SUN Jing, LIU Su-qin. Effect of Tamoxifen Combined with Gestrinone on the Prevention of Postoperative Recurrence of Endometriosis. JOURNAL OF CLINICAL RESEARCH, 2020, 37(1): 36-38.
2020, Vol. 37 
