Effect of Two Reverse Added Solutions on Sex Hormone and Bone Mineral Density upon GonadotropinReleasing Hormone (GnRH) Inhibitors in the Treatment of Pelvic Endometriosis (EM)
Abstract：【Objective】To compare the effect of two reverse added solutions on sex hormone and bone mineral density upon gonadotropinreleasing hormone (GnRH) inhibitors in the treatment of pelvic endometriosis (EM).【Methods】Eighty patients with requirement for fertility who were treated with conservative laparoscopic surgery for severe pelvic endometriosis were collected, and were randomly divided into control group and experimental group, 40 cases in each group. The control group were given with the GnRHa 3.6mg/28d ，seven times totally. On the basis of the control group, the experimental group was added with vitamin D3. At time before each treatment and on the fourth week, twelfth week, sixteenth week, twentieth week, twentyfourth week and menstrual cycle , the conventional ultrasound reexamination and follicle stimulating prime (FSH), luteinizing prime (LH) ,the change of E2 and bone density scan were detected; osteoporosis prevention and treatment effect of two groups of patients were compared.【Results】(1)In the two groups ,at 4th w, 12th w, 16th w, 20th w and 24th w after the treatment, the levels of serum E2, FSH, LH were significantly reduced , the difference was significant (P<0.05); at 4th w, the medication was reduced almost to the level of menopaus , FSH and LH were in a low level and serum E2, FSH and LH of the two groups had no significant difference (P>0.05). (2) Comparing with those before treatment, the difference of bone density of the two groups at 4th w, 8th w, 12th w after treatment were not statistically significant (P>0.05); 16 weeks, 20 weeks and 24 weeks after medication and the return of menses, the bone density in both groups was significantly decreased, the difference of the control had statistical significance comparing with those of the treatment group and that before treatment (P<0.05), compared to that before treatment, there were differences with the experimental group ,but no statistical significance (P>0.05).【Conclusion】 GnRH inhibitor, combined with a small dose of estrogen, calcium and vitamin D3 in patients with pelvic EM is able to prevent low estrogen level and osteoporosis, the effect sounds better.
李博 杨静 胡赛男 周绍明 龚颖萍. 两种反向添加方案对GnRH抑制剂治疗盆腔子宫内膜异位症术后患者性激素水平和骨质疏松的影响[J]. 医学临床研究, 2016, 33(3): 427-429.
LI Bo,YANG Jing,HU Sainan,et al. Effect of Two Reverse Added Solutions on Sex Hormone and Bone Mineral Density upon GonadotropinReleasing Hormone (GnRH) Inhibitors in the Treatment of Pelvic Endometriosis (EM). JOURNAL OF CLINICAL RESEARCH, 2016, 33(3): 427-429.
2016, Vol. 33 
