医学临床研究
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医学临床研究  2019, Vol. 36 Issue (12): 2361-2363    DOI: 10.3969/j.issn.1671-7171.2019.12.024
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丙泊酚静脉麻醉在肺癌根治术中的效果及对细胞因子的影响
葛莉1, 朱美华2
1.江苏省如皋市人民医院麻醉科,江苏 如皋 226500;
2.江苏省第二中医院,江苏 南京 210000
Effects of Propofol Intravenous Anesthesia on Hemodynamic and Cytokines in Radical Resection of Lung Cancer
GE Li, ZHU Mei-hua
Department of Anesthesiology, Rugao People's Hospital of Jiangsu Province, Jiangsu Rugao 226500
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摘要 【目的】探讨丙泊酚全凭静脉麻醉在肺癌根治术中的麻醉效果及对患者血清细胞因子的影响。【方法】拟实施肺癌根治手术的患者70例,随机分为两组,各35例;对照组采用七氟烷吸入麻醉,观察组采用丙泊酚全凭静脉麻醉;比较两组的血流动力学指标、血清细胞因子及术中麻醉效果。【结果】入室时(T0),两组平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)值相比较差异均无显著性(P>0.05);单肺通气开始前即刻(T1)、单肺通气结束前即刻(T2)、术毕(T3)时,对照组MAP、HR值低于观察组(P<0.05);T1至拔管后即刻(T4),两组SpO2值相比较差异均无显著性(P>0.05);术前两组的血清白细胞介素-6(IL-6)、IL-8、IL-10水平相比较差异均无显著性(P>0.05);术后2h观察组血清IL-6、IL-8水平低于,IL-10水平高于对照组(P<0.05);两组患者术中的麻醉效果相比较差异无显著性(P>0.05)。【结论】丙泊酚全凭静脉麻醉在肺癌根治术中应用较七氟烷吸入麻醉对患者的血流动力学指标、细胞因子水平的影响更小。
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葛莉
朱美华
关键词 肺肿瘤二异丙酚/药理学麻醉    
Abstract【Objective】To investigate the anesthetic effect of total intravenous propofol anesthesia in radical resection of lung cancer and study its effect on serum cytokines. 【Methods】A total of 70 patients who underwent radical surgery for lung cancer were randomly divided into two group, with 35 cases in each group. The control group received sevoflurane inhalation anesthesia, while the observation group received propofol intravenous anesthesia. Hemodynamic parameters, serum cytokines and intraoperative anesthesia were compared between the two groups. 【Results】At the time of admission (T0), the difference of MAP, HR and SpO2 between the two group was not statistically significant (P>0.05). At the time of T1(start of ventilation),T2 (end of ventilation) and T3 (end of surgery), the measured values of MAP and HR in the control group were lower than those in the observation group (P<0.05). Levels of SpO2 from T1~T4 (extubation) were not significant differences between the two group (P>0.05). There were no significant differences in serum IL-6, IL-8 and IL-10 levels between two group before surgery (P>0.05). At 2h after operation, the serum levels of IL-6 and IL-8 in the observation group were lower (P<0.05) than those in the control group; While the serum IL-10 level at 2h after surgery in the observation group were higher than that in the control group (P<0.05). The anesthetic effects of the two groups was no significant difference (P>0.05). 【Conclusion】The effects of total intravenous propofol anesthesia on hemodynamic parameters and cytokine balance in patients undergoing radical resection of lung cancer are less than those of sevoflurane inhalation anesthesia.
Key wordsLung Neoplasms    Propofol/PD    Anesthesia
收稿日期: 2019-02-26     
PACS:  R734.2  
引用本文:   
葛莉, 朱美华. 丙泊酚静脉麻醉在肺癌根治术中的效果及对细胞因子的影响[J]. 医学临床研究, 2019, 36(12): 2361-2363.
GE Li, ZHU Mei-hua. Effects of Propofol Intravenous Anesthesia on Hemodynamic and Cytokines in Radical Resection of Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(12): 2361-2363.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.12.024     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I12/2361
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