Effects of Programmed Analgesia and Sedation Combined with Moderate Hyperventilation on Recovery Time and Cognitive Function in Patients with Severe Craniocerebral Injury
ZOU Yan-qun
Critical care medicine,Sichuan Ziyang first people's Hospital ,Sichuan Ziyang 641300
Abstract：【Objective】To explore the effect of programmed sedation and analgesia combined with moderate hyperventilation on recovery time and cognitive function of patients with severe craniocerebral injury after operation.【Methods】Ninty cases of severe craniocerebral injury collected in our hospital were selected as the research objects. All the selected patients were randomly divided into two groups, 45 cases in each group. The control group was treated with moderate hyperventilation, while the observation group was treated with programmed analgesia on the basis of the control group. The monitoring indexes of cerebral oxygen consumption(ICP、SjO2、CEO2、AVDO2), recovery time, sedative and analgesic effects and cognitive function were compared between the two groups. 【Results】ICP and SjO2 in the observation group were significantly higher than those in the control group (P<0.05), while CEO2 and AVDO2 in the observation group were significantly lower than those in the control group (P<0.05); the recovery time, extubation time and speaking time in the observation group were significantly shorter than those in the control group (P<0.05); SAS, VAS and RSS scores in the observation group were significantly lower than those in the control group (P<0.05); the cognitive efficiency of the observation group was significantly higher than that of the control group (P<0.05).【Conclusion】During the treatment of severe craniocerebral injury, programmed sedation and analgesia combined with moderate hyperventilation can fully relieve pain, reduce stress, reduce brain oxygen consumption and produce good brain protection.
邹燕群. 程序化镇痛镇静联合适度过度通气对重症颅脑损伤患者术后苏醒时间及认知功能的影响[J]. 医学临床研究, 2020, 37(1): 12-14.
ZOU Yan-qun. Effects of Programmed Analgesia and Sedation Combined with Moderate Hyperventilation on Recovery Time and Cognitive Function in Patients with Severe Craniocerebral Injury. JOURNAL OF CLINICAL RESEARCH, 2020, 37(1): 12-14.
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2020, Vol. 37 
