Abstract：【Objective】 To investigate the relationship of chloride intracellularchannel 1expression (CLIC1) with invasion, metastasis and prognosis of gastric cancer (GC). 【Methods】 The GC tissues and adjacent tissues were obtained from 94 patients. The expression of CLIC1 mRNA and protein were detected. The correlation of CLIC1 protein expression with gastric cancer clinical characteristics was analyzed. Multivariate Cox proportional model was applied to reveal the influencing factors of poor prognosis of gastric cancer. 【Results】 The positive expression rate of CLIC1 protein in GC adjacent tissues was 25. 0% (23/94), which was significantly lower than that of the GC tissues 86% (81/94) (P<0.01) .The positive expression of CLIC1 was not correlated with age, gender, tumor metastasis, however, it was related with tumor differentiation, lymph node metastasis, depth of invasion and TNM stage (all P<0.05). The expression level of CLIC1 mRNA in gastric cancer tissues was significantly higher than that in adjacent normal tissues (P<0.05). The median survival time of patients with low expression of CLIC1 protein was over 29 months, which was significantly longer than that of patients with positive expression for 25 months ( P<0.05). The 5-year survival rate of patients with low expression of CLIC1 protein was 63.9%, which was significantly higher than 20.7% of patients with positive expression of CLIC1 protein (P<0.05). GC invasion depth, lymph node metastasis, TNM stage and CLIC1 protein expression were independent prognostic factors for gastric cancer survivals (P<0.01). 【Conclusion】 CLIC1 plays an important role in the genesis and development of gastric cancer. High expression of CLIC1 is closely correlated with the invasion and metastasis of GC.
王志强, 孙鹏, 高淳, 徐铭, 张云鹏, 程大庆, 王珏. 细胞内氯离子通道蛋白-1表达与胃癌侵袭转移的相关性研究[J]. 医学临床研究, 2019, 36(10): 1935-1938.
WANG Zhi-qiang,SUN Peng, GAO Chun,et al. Study on Correlation of CLIC1 Protein Expression with Invasion and Metastasis of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(10): 1935-1938.
[1] 张静, 冯晓云, 林燕. 胃癌侵袭转移危险因素分析[J]. 山西医科大学学报, 2017, 48(8):836-839. [2] Zheng DL, Huang QL, Zhou F, et al. PA28β regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1[J]. J Cell Biochem, 2012,113(5):1537-1546. [3] Izumi D, Ishimoto T, Miyake K, et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer[J]. Int J Cancer, 2016, 138(5):1207-1219. [4] Han S, Wu X, Guo Y, et al. Abstract 5162: Id1 is an oncogenic target of RNA binding protein HuR in gastric cancer[J]. Cancer Res, 2016, 76(14 Supplement):5162. [5] 杨庭松, 孙营营, 张小兵,等. CXCL-1促进胃癌细胞迁移和侵袭机制探讨[J]. 中华肿瘤防治杂志, 2017, 24(13):881-887. [6] Chikman B, Davidson T, Kais H, et al. Is there an association between invasive lobular carcinoma of the breast and a family history of gastric cancer[J]. Fam Cancer, 2016, 15(1):41-47. [7] 李丹, 黄宝俊, 赵丹懿. 远端上游元件结合蛋白1在胃癌中的表达及其对胃癌细胞增殖和侵袭能力的影响[J]. 中国医科大学学报, 2017, 46(7):587-590. [8] Wang L, Yin J, Wang X, et al. C-type lectin-like receptor 2 suppresses AKT signaling and invasive activities of gastric cancer cells by blocking expression of PI3K subunits[J].Gastroenterology,2016, 150(5):1183-1195. [9] Qin R, Zhao J, Qin W, et al. Discovery of non-invasive glycan biomarkers for detection and surveillance of gastric cancer[J]. J Cancer, 2017, 8(10):1908-1916.
2019, Vol. 36 
