Abstract：【Objective】To compare the effect of TS and SOX in postoperative adjuvant chemotherapy of gastric cancer. 【Methods】A total of 96 patients with postoperative adjuvant chemotherapy for gastric cancer were randomly divided into two groups. There were 49 patients in the observation group who were treated with SOX (Oxaliplatin + Teggio capsule), while 47 patients in the control group were treated with the TS regimen (paclitaxel liposome + tigeo capsule). The treatment course in both groups lasted for 5 cycles. The clinical efficacy, recurrence, and adverse reactions of the two groups were compared during the postoperative adjuvant chemotherapy with 3-year follow-up. 【Results】The total effective rate of the observation group was higher than that of the control group (59.2% vs 36.2%, P<0.05); The clinical benefit rate of the observation group was higher than that of the control group (83.7% vs 63.8%, P<0.05). The overall improvement rate of life quality in the observation group was higher than that of the control group (55.1% vs 31.9%, P<0.05). CEA and AFP of two groups showed no differences before and after treatment (P>0.05). The levels of CA199, CA125 and NSE in the observation group were significantly decreased after treatment ( P<0.05), while those tumor markers in the observation group were significantly lower than those in the control group ( P<0.05). The incidence rate of marrow suppression and liver function damage between the two groups did not show significant difference (P>0.05), while the incidence rate of nausea, vomiting, diarrhea and pain in the observation group were significantly lower than those in the control group (P<0.05). The RSF and OS in the observation group were significantly higher than those in the control group within 3 years (P<0.05); The peritoneal metastasis of the observation group was significantly lower than that of the control group (P<0.05). 【Conclusion】 Compared to TS chemotherapy, SOX chemotherapy has better clinical effects in adjuvant chemotherapy for gastric cancer with lower recurrence and metastasis rates and less incidence of adverse reactions.
秦海运, 李凤珍, 王宁, 胡鑫. TS和SOX两种化疗方案在胃癌患者术后辅助化疗中的疗效比较[J]. 医学临床研究, 2019, 36(3): 423-425.
QIN Hai-yun, LI Feng-zhen, WANG Ning,et al. Comparison of Effect, Recurrence, Metastasis and Adverse Reactions of TS and SOX in Postoperative Adjuvant Chemotherapy for Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 423-425.
2019, Vol. 36 
