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医学临床研究  2019, Vol. 36 Issue (3): 455-457    DOI: 10.3969/j.issn.1671-7171.2019.03.013
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清热消毒汤灌肠联合酚妥拉明治疗重症脓毒血症患者的疗效及对相关指标的影响
董海生, 于朝春, 林坚, 何小云
上海中医药大学附属上海市中西医结合医院ICU,上海 200082
Effect of Qing Re Xiao Du Soup Combined with Phentolamine on Immune Inflammation and Hemodynamics in Patients with Severe Sepsis
DONG Hai-sheng, YU Chao-chun, LIN Jian,et al
Shanghai The Hospital of Shanghai Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
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摘要 【目的】探讨清热消毒汤灌肠联合酚妥拉明治疗重症脓毒血症患者的疗效及对免疫炎症反应与血流动力学指标的影响。【方法】96例重症脓毒血症患者随机分为两组,每组48例。对照组采用常规加酚妥拉明治疗,观察组在对照组基础上加用清热解毒汤灌肠,比较两组患者的疗效、免疫炎症反应和血流动力学指标及不良反应。【结果】观察组总有效率为97.9%(47/48),显著高于对照组的85.4%(41/48)(P<0.05);治疗后观察组患者CD4+、CD8+、白介素-6(IL-6)、C-反应蛋白(CRP)、降钙素原 (PCT)水平改善程度显著优于对照组(P<0.01);治疗后两组患者的心脏指数(CI)、血管外肺水指数(EVLWI)、全身血管阻力指数(SVRI)、胸腔内血容积指数(ITBVI)较治疗前均明显改善(P<0.05);且观察组各指标改善程度显著优于对照组(P<0.05);两组患者治疗期间均未出现不良反应。【结论】清热消毒汤灌肠联合酚妥拉明治疗重症脓毒血症患者疗效确切,可以明显改善患者的免疫炎症反应与血流动力学指标。
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董海生
于朝春
林坚
何小云
关键词 酚妥拉明/治疗应用脓毒症    
Abstract:【Objective】To explore the effect of Qing Re Xiao Du Soup (dissolving decoction) combined with Phentolamine on immune inflammation and hemodynamics in patients with severe sepsis. 【Methods】A total of 96 patients with severe sepsis were random divided into two groups with 48 cases in each group. Patients in the control group were treated with Phentolamine injections were administered on the basis of routine treatment, while patients in the observation group were treated with Qing Re Xiao Du Soup on the basis of phentolamine injections. The clinical efficacy, immune inflammation index, hemodynamic index and adverse reactions of the two groups were recorded and compared. 【Results】The total effective rate was 97.9% (47/48) in the observation group, which was higher than 85.4% (41/48) in the control group (P<0.05). After treatment, levels of CD4+, CD8+, IL- 6, CRP and PCT in the observation group were improved significantly better than those in the control group (P <0.01). After treatment, the cardiac index (CI), extravascular lung water index (EVLWI), systemic vascular resistance index (SVRI), and intrathoracic blood volume index (ITBVI) were significantly improved in both groups (P<0.05). The improvement of each index in the observation group was significantly better than that in the control group (P<0.05). There were no adverse reactions during the treatment period.【Conclusion】 Qing Re Xiao Du Soup combined with phentolamine is effective in the treatment of severe sepsis and can obviously improve the immune inflammatory reaction and hemodynamic index of the patients.
Key wordsPhentolamine/TU    Sepsis
收稿日期: 2018-05-29     
PACS:  R558.2  
引用本文:   
董海生, 于朝春, 林坚, 何小云. 清热消毒汤灌肠联合酚妥拉明治疗重症脓毒血症患者的疗效及对相关指标的影响[J]. 医学临床研究, 2019, 36(3): 455-457.
DONG Hai-sheng, YU Chao-chun, LIN Jian,et al. Effect of Qing Re Xiao Du Soup Combined with Phentolamine on Immune Inflammation and Hemodynamics in Patients with Severe Sepsis. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 455-457.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.03.013     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I3/455
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