Abstract：【Objective】To study the effects and prognosis of docetaxel alone and its combination with thiotepa in the treatment of metastatic breast cancer(MBC). 【Methods】A total of 86 patients with MBC were divided into the docetaxel treatment group (group A,n=42) and docetaxel combined with thiotepa group (group B,n=44). The short-term curative effect, adverse reactions and survival rate were compared between the two groups. 【Results】The effective rate of treatment and clinical control rate in group A were 50% and 80.95%, respectively, while those in group B were 56.82% and 90.91%, respectively; the differences were not statistically significant (P>0.05). The neutropenia, anemia, thrombocytopenia and adverse reactions in group B were more serious than those in group A; and the differences were statistically significant (P<0.05). The progression-free survival time was 12.64 months in group A and 14.26 months in group B. There was no significant difference between the two groups (P>0.05). The 1-year, 2-year and 3-year local control rates of tumor and survival rates were 42.8%, 19.05%, 2.38% and 47.62%, 21.43%, 4.76% in group A, while those in group B were 50%, 22.73%, 11.36% and 54.55%, 31.82%, 15.91%. The 3-year survival rate showed significant difference (P<0.05). There was no significant difference in the rate of tumor control and survival between the two groups at 1 year and 2 years (P>0.05), but the 3-year survival rate in group A was lower than that in group B, and the difference was significant (P<0.05). 【Conclusion】The short-term and long-term effects of docetaxel alone and its combination with thiotepa are similar in the treatment of metastatic breast cancer. Although the toxicity of docetaxel alone is smaller, its 3-year survival rate is lower than that of the combination group. The specific chemotherapy should be chosen according to the actual condition of patients.
李爱峰. 多西他赛单药及其联合塞替派治疗转移性乳腺癌的疗效比较[J]. 医学临床研究, 2018, 35(5): 918-920.
LI Ai-feng. Comparison of Effects of Docetaxel Alone and Its Combination with Thiotepa in the Treatment of Metastatic Breast cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(5): 918-920.
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