Study on the Change of Time Domain Index of Heart Rate Variability in Patients with Peripartum Cardio-myopathy and Pregnancy Induced Hypertension and ItsMechanism
摘要【目的】探讨围产期心肌病（PPCM）患者和妊娠高血压疾病（PIH）患者心率变异性（HRV）时域指标变化和机制。【方法】收集PPCM患者30例（PPCM组），PIH患者30例（PIH组），正常体检者30例（对照组），比较三组 HRV时域和超声心动图指标。【结果】PPCM组和PIH组的窦性心搏间期NN标准差（SDNN）、全程记录中每5 min NN间期平均值的标准差（SDANN）、全程相邻NN间期差值的均方根（RMSSD）、相邻RR间期差值（PNN50）值均显著低于对照组，且PPCM组显著低于PIH组，其差异有显著性（P＜0．05）。三组室壁厚度比较无显著性差异（P＞0．05），PPCM组心室前后径、运动幅度和左室射血分数与PIH组、对照组比较均有显著性差异（P＜0．05）；但PIH组与对照组比较均无显著性差异（P＞0．05）。【结论】PPCM患者妊娠后期心脏组织结构和功能发生改变，因心脏重构致自主神经功能损害， HRV时域指标下降；PIH患者交感神经和副交感神经平衡紊乱，心率变异性时域指标下降。
Abstract：[Objective]To explore the change of time domain index of heart rate variability(HRV)in patients with peripartum cardiomyopathy(PPCM)and pregnancy induced hypertension(PIH)and its mechanism.[Meth-ods]Totally 30 patients with PPCM(PPCM group),30 patients with PIH(PIH group)and 30 normal healthy peo-ple(control group)were collected.The indexes of time domain of HRV and echocardiography among 3 groups were compared.[Results]SDNN,SDANN,RMSSD and PNN50 in PPCM group and PIH group were markedly lower than those in control group,and those in PPCM group were markedly lower than those in PIH group,and there was significant difference(P <0.05).There was no significant difference in ventricular wall thickness a-mong 3 groups(P >0.05).There were significant differences in ventricular antero-posterior diameter,motion amplitude and EF between PPCM group and PIH group or control group(P<0.05),but there was no significant difference between PIH group and control group(P >0.05).[Conclusion]PPCM patients at third trimester of pregnancy have the change of cardiac structure and function due to autonomic nerve function damage induced by cardiac remodeling and the decreasing of time domain index of HRV.Patients with PIH have the disorder of the balance between sympathetic and parasympathetic nerve and the decreasing of time domain index of HRV.
引用本文:
李晶%李晓吉. 围产期心肌病和妊娠高血压疾病患者心率变异性时域指标变化及机制研究[J]. 医学临床研究, 2014, 31(6): 1135-1137.
LIJing%LIXiao-ji. Study on the Change of Time Domain Index of Heart Rate Variability in Patients with Peripartum Cardio-myopathy and Pregnancy Induced Hypertension and ItsMechanism. 医学临床研究, 2014, 31(6): 1135-1137.
2014, Vol. 31 
