Abstract：【Objective】To explore the result of quantitative computed tomography (CT) and its clinical significance on patients with pulmonary alveolar proteinosis (PAP) after bronohoalveolar lavage. 【Methods】The clinical data of 30 patients with PAP were selected. All patients were treated with BAL.The pulmonary function indexes of patients were measured by pulmonary function test before and after treatment [forced vital capacity (FVC), carbon monoxide diffusion volume (DLCO), forced expiratory volume (FEV1) in 1 second, maximum ventilation value (MVV) / percentage of predicted value. That is, FVC%, DLCO%, FEV1%,MVV%].Pulmonary ventilation function indexes [arterial oxygen / carbon dioxide partial pressure (PaO2 and PaCO2), blood oxygen saturation (SaO2)] were compared before and after treatment. The mean density of lung, the total volume of lung gas, the total mass of lung, the mean value of CT and so on were measured by quantitative CT. MMRC score was used to evaluate the degree of dyspnea. 6 min walking test was used to evaluate dyspnea symptoms and exercise endurance.【Results】The difference of FVC%, FEV1%, PaCO2 before and after BAL was statistically significant (P>0.05). The DLCO%, MVV%, PaO2, SaO2 value after BAL was significantly higher than that before BAL (P<0.05). The mean lung CT value, total lung weight and lung density were significantly lower than those before BAL (P<0.05). The total volume of lung gas was significantly higher than that before BAL (P<0.05). The MMRC score of patients after BAL was significantly lower than that before BAL, and the 6 min -walking distance was significantly higher than that of BAL (P<0.05). 【Conclusion】The clinical effect of BAL in the treatment of PAP is better. Quantitative CT can be used to evaluate the effect of bronohoalveolar lavage.
王芬. 定量CT对肺泡蛋白沉着症患者支气管肺泡灌洗的效果的评价[J]. 医学临床研究, 2018, 35(10): 1914-1916.
WANG Fen. Evaluation of the Effect of Quantitative CT on Bronchoalveolar Lavage in Patients with Pulmonary Alveolar Proteinosis. JOURNAL OF CLINICAL RESEARCH, 2018, 35(10): 1914-1916.
[1] Huaringa AJ, Francis WH. Pulmonary alveolar proteinosis: a case report and world literature review[J].Respirology Case Reports,2016, 4 (6): e00201. [2] Rennis DK, Thomas VD, Krishnakumar EV,et al. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia [J].Lung India Official Organ of Indian Chest Society,2015, 32 (2): 162-164. [3] 陈志远,张志浩,车审言.大容量全肺灌洗术医疗护理常规及操作规程[M].北京:北京科学技术出版社,2004:10. [4] 杨兆辉,段瑞祥,杨晶,等.纤维支气管镜与肺泡灌洗术治疗老年重症肺部感染患者的疗效分析[J].中华医院感染学杂志,2016,26(6):1300-1302. [5] Rehman SU, Hammersley JR. Pulmonary Alveolar Proteinosis: Crazy Paving to Whole Lung Lavage [J].Mayo Clinic Proc,2016, 91 (11): 1673-1674. [6] 严薇,李颖倡,张晓华.全肺灌洗术治疗肺泡蛋白沉积症的疗效观察[J].医学临床研究,2016,33(7):1424-1426. [7] 陈敏,刘双林,张明周,等.全肺灌洗治疗肺泡蛋白沉积症的疗效观察[J].中国医刊,2016,51(10):39-41. [8] 何顺清,唐西平,何飞鸿,等肺.泡蛋白沉积症的影像学诊断与临床分析[J].临床肺科杂志,2014,19(5):841-844. [9] 叶文卫,刘勇彬,刘琴.肺泡蛋白沉着症支气管肺泡灌洗术前后胸部CT主要表现[J].CT 理论与应用研究,2014,23(2):293-298. [10] 刘勇彬,曾庆思,马壮,等.定量CT对肺泡蛋白沉着症肺泡灌洗术前后的应用分析[J].临床放射学杂志,2014,33(3):365-368.
2018, Vol. 35 
