颈动脉超声指标及血浆miR-146a、miR-214相对表达量与高脂血症患者发生冠心病的相关性

doi:10.3969/j.issn.1671-7171.2026.07.026

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摘要 【目的】探讨颈动脉超声指标及血浆miR-146a、miR-214相对表达量与高脂血症患者发生冠心病的相关性。【方法】选取2022年7月至2024年7月两院收治的90例疑似高风险冠心病的高脂血症患者,根据冠状动脉造影结果将患者分为观察组(合并冠心病,n=68)和对照组(未合并冠心病,n=22)。比较两组一般资料、实验室指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、miR-146a、miR-214]、颈部血管超声指标[内膜-中膜厚度(IMT)、颈动脉Crouse斑块积分]、动态动脉僵硬指数(AASI),分析高脂血症患者发生冠心病的影响因素,基于颈动脉超声指标及血浆miR-146a、RNA-214相对表达量建立高脂血症患者发生冠心病的预测模型,并验证。【结果】两组患者TG、HDL-C水平比较,差异无统计学意义(P>0.05);观察组TC、IMT、AASI、颈动脉Crouse斑块积分、miR-146a、miR-214 均显著高于对照组,差异有统计学意义(P<0.05)。Logistic回归分析显示,TC(OR=4.483)、IMT(OR=19.739)、AASI(OR=2.854)、颈动脉Crouse斑块积分(OR=4.999)、miR-146a(OR=12.849)、miR-214(OR=3.438)是高脂血症患者发生冠心病的影响因素(P<0.05)。ROC曲线分析显示,颈动脉超声指标及血浆miR-146a、miR-214相对表达量模型预测高脂血症患者发生冠心病的灵敏度为0.868,特异度为0.955,曲线下面积为0.962。【结论】颈动脉超声指标及血浆miR-146a、miR-214相对表达量与高脂血症患者发生冠心病有关,建立综合预测模型可用于辅助预测冠心病的发病风险,预测效能良好。

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	马丽平
	陈静
	赵伟

关键词 ：高脂血症, 冠心病, 颈动脉, 超声检查, 微RNAs

Abstract：【Objective】 To explore the correlation between carotid ultrasound parameters, relative expression levels of plasma miR-146a, miR-214 and coronary heart disease (CHD) in patients with hyperlipidemia. 【Methods】 A total of 90 hyperlipidemic patients with suspected high risk of CHD admitted to the two hospitals from July 2022 to July 2024 were enrolled. According to coronary angiography results, patients were divided into observation group (complicated with CHD, n=68) and control group (without CHD, n=22). General data, laboratory indicators including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), miR-146 and miR-214, as well as carotid ultrasound parameters including intima-media thickness (IMT), and carotid Crouse plaque score ambulatory arterial stiffness index (AASI) were compared between the two groups. Influencing factors for CHD in hyperlipidemic patients were analyzed, and a prediction model based on carotid ultrasound indicators and plasma miR-146a, miR-214 expression was constructed and verified. 【Results】 There was no significant difference in TG and HDL-C levels between the two groups (P>0.05). TC, IMT, AASI, carotid Crouse plaque score, miR-146a and miR-214 in the observation group were significantly higher than those in the control group (P<0.05). Logistic regression analysis showed that TC (OR=4.483), IMT(OR=19.739), AASI (OR=2.854), carotid Crouse plaque score (OR=4.999), miR-146a (OR=12.849) and miR-214 (OR=3.438) were risk factors for CHD in hyperlipidemic patients (P<0.05). ROC curve analysis demonstrated that the combined model had a sensitivity of 0.868, specificity of 0.955 and AUC of 0.964 for predicting CHD. 【Conclusions】 Carotid ultrasound parameters and relative expression of plasma miR-146a, miR-214 are correlated with the occurrence of CHD in hyperlipidemic patients. The established comprehensive prediction model has favorable predictive efficiency and can assist in evaluating the risk of CHD.

Key words： Hyperlipidemias Coronary Disease Carotid Arteries Ultrasonography MicroRNAs

收稿日期: 2026-01-08

中图分类号:

R589.21

引用本文:

马丽平, 陈静, 赵伟. 颈动脉超声指标及血浆miR-146a、miR-214相对表达量与高脂血症患者发生冠心病的相关性[J]. 医学临床研究, 2026, 43(7): 1148-1151.
MA Liping, CHEN Jing, ZHAO Wei. Correlation between Carotid Ultrasound Parameters, Relative Expression of Plasma miR-146a and miR-214 and Coronary Heart Disease in Patients with Hyperlipidemia. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1148-1151.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.07.026 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I7/1148

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