经鼻间歇正压通气治疗新生儿呼吸窘迫综合征的临床效果及对患儿血气指标、神经发育的影响

doi:10.3969/j.issn.1671-7171.2026.06.017

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摘要 【目的】探讨经鼻间歇正压通气(NIPPV)治疗新生儿呼吸窘迫综合征(NRDS)的临床效果及对患儿血气指标、神经发育的影响。【方法】选择2019年8月至2024年8月本院收治的148例NRDS患儿,根据不同的通气方案将患儿分为观察组和对照组,每组74例。观察组采用NIPPV模式,对照组采用经鼻持续气道正压通气(N-CPAP)模式。比较两组患儿治疗情况、动脉血二氧化碳分压(PaCO₂)、动脉血氧分压(PaO₂)、pH 值、氧合指数(OI)及神经发育情况。【结果】观察组住院时间、氧疗时间均短于对照组,呼吸暂停次数少于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者PaCO₂、OI均低于治疗前,pH值、PaO₂均高于治疗前,且观察组PaCO₂、OI均低于对照组,pH值、PaO₂高于对照组,差异均有统计学意义(P<0. 05)。治疗12个月后,观察组智力量表评分≥85分、运动量表评分≥85分和发育商(DQ)评分≥85分所占比例均高于对照组,差异均有统计学意义(P<0.05)。观察组、对照组不良反应总发生率分别为13.51%(10/74)、14.86% (11/74),两组比较,差异无统计学意义(χ²=0.055,P>0.05)。【结论】NIPPV可快速改善NRDS患儿呼吸功能,显著改善患儿临床症状氧合功能,纠正低氧血症,有助于维持机体酸碱平衡,且安全性良好。

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	李宾

关键词 ：呼吸窘迫综合征,新生儿, 呼吸,人工, 儿童发育

Abstract：【Objective】 To investigate the clinical effect of nasal intermittent positive pressure ventilation (NIPPV) in the treatment of neonatal respiratory distress syndrome (NRDS) and its influence on blood gas indexes and neurodevelopment of neonates. 【Methods】 A total of 148 neonates with NRDS admitted to our hospital from August 2019 to August 2024 were selected and divided into observation group and control group according to different ventilation regimens, with 74 cases in each group. The observation group was treated with NIPPV mode, while the control group received nasal continuous positive airway pressure (N-CPAP) mode. The treatment outcomes, arterial partial pressure of carbon dioxide (PaCO₂), arterial partial pressure of oxygen (PaO₂), pH value, oxygenation index (OI) and neurodevelopment status were compared between the two groups. 【Results】 The hospitalization stay and oxygen therapy duration of the observation group were shorter, and the number of apnea episodes was less than those of the control group, with statistically significant differences (P<0.05). After treatment, PaCO₂ and OI decreased, while pH value and PaO₂ increased in both groups compared with baseline; the observation group had lower PaCO₂ and OI, as well as higher pH value and PaO₂ than the control group, and all differences were statistically significant (P<0.05). At 12 months after treatment, the proportions of neonates with intelligence scale score ≥85, motor scale score ≥85 and developmental quotient (DQ) ≥85 in the observation group were all higher than those in the control group, with statistically significant differences (P<0.05). The total incidence of adverse reactions in the observation group and control group was 13.51% (10/74) and 14.86% (11/74) respectively, and there was no statistically significant difference between the two groups (χ²=0.055, P>0.05). 【Conclusion】 NIPPV can rapidly improve respiratory function and clinical symptoms, significantly ameliorate oxygenation function and correct hypoxemia in neonates with NRDS, help maintain the body's acid-base balance, and possesses favorable safety.

Key words： Respiratory Distress Syndrome, Newborn Respiration, Artificial Child Development

收稿日期: 2025-08-12

中图分类号:

R725.638

引用本文:

李宾. 经鼻间歇正压通气治疗新生儿呼吸窘迫综合征的临床效果及对患儿血气指标、神经发育的影响[J]. 医学临床研究, 2026, 43(6): 941-944.
LI Bin. Clinical Effect of Nasal Intermittent Positive Pressure Ventilation in the Treatment of Neonatal Respiratory Distress Syndrome and its Influence on Blood Gas Indexes and Neurodevelopment of Neonates. JOURNAL OF CLINICAL RESEARCH, 2026, 43(6): 941-944.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.06.017 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I6/941

[1] 张崇巽,李政,高翔羽. 新生儿急性呼吸窘迫综合征临床研究进展[J].中华围产医学杂志,2025,28(8):711-715.
[2] 庄晓玲,边程鹏,肖梅,等. 高剂量猪肺磷脂注射液分别联合HFOV与CPAP对VLBWI呼吸窘迫综合征患儿血气指标的影响[J].川北医学院学报,2025,40(8):1049-1052.
[3] 谢雅欣,符鸿福,王红. 急性呼吸窘迫综合征体外膜氧合辅助呼吸治疗研究进展[J].中国医药,2025,20(8):1255-1258.
[4] 何旭,冼家明,池丽霞. 两种鼻塞用于经鼻间歇正压通气初始治疗新生儿呼吸窘迫综合征的比较[J].中国妇幼健康研究,2025,36(10):83-88.
[5] 张慧,彭万胜. NIPPV和NCPAP联合LISA技术治疗早产儿呼吸窘迫综合征效果观察[J].山东医药,2022,62(22):71-74.
[6] 李莹莹,戴立英,朱峰,等. NHFOV、NIPPV、NCPAP疗法在早产儿呼吸窘迫综合征治疗中的应用对比观察[J].山东医药,2022,62(18):72-76.
[7] SWEET D G, CARNIELLI V, GREISEN G, et al. European consensus guidelines on the management of respiratory distress syndrome-2016 update[J].Neonatology,2017,111(2):107-125.
[8] 范存仁. CDCC婴幼儿智能发育量表的编制[J].心理学报,1989(2):130-140.
[9] GUO M, ZHU J, YANG T, et al. Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders[J].Nutr Neurosci,2019,22(9):637-647.
[10] 荣辉,毛国顺,高敏,等. 微创肺表面活性物质治疗早产儿呼吸窘迫综合征对发育结局的影响[J].中国现代医学杂志,2022,32(24):6-12.
[11] GUIDELINE B T S. Non-invasive ventilation in acute respiratory failure[J].Thorax,2002, 57(3): 192-211.
[12] 杜志云,李书秀,许海娟,等. 无创间歇正压通气模式对新生儿呼吸窘迫综合征患儿肺换气功能、预后的影响[J].中南医学科学杂志,2023,51(5):760-762.
[13] 张兴宇.NIPPV模式和NCPAP模式对新生儿呼吸窘迫综合征的治疗对比分析[J].中外医疗, 2020, 39(25):10-12.