Abstract：【Objective】 To investigate the analgesic efficacy of preoperative flurbiprofen axetil combined with transversus abdominis plane (TAP) block after laparoscopic total hysterectomy (LTH). 【Methods】 A total of 102 patients scheduled for LTH were randomly divided into a control group (receiving preoperative flurbiprofen axetil analgesia) and an observation group (receiving preoperative flurbiprofen axetil plus TAP block), with 51 cases in each group. The following outcomes were compared between the two groups: analgesic and sedative effects, time to awakening and extubation, levels of inflammatory factors [prostaglandin E2 (PGE2), tumor necrosis factor α (TNF-α), high-mobility group box 1 protein (HMGB-1)], Bruggrmann Comfort Scale (BCS) scores, Quality of Recovery-40 (QoR-40) scores, and incidence of adverse reactions. 【Results】 The observation group required lower doses of remifentanil and propofol, had a lower rescue analgesia rate, and showed lower Ramsay sedation scores at 2 h postoperatively compared with the control group (P<0.05). Awakening time and extubation time in the observation group were shorter than those in the control group (P<0.05). At 48 h after surgery, levels of PGE2, TNF-α, and HMGB-1 in the observation group were lower than those in the control group (P<0.05). BCS and QoR-40 scores at 6 h and 1 day postoperatively in the observation were higher than those in the control group (P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Preoperative flurbiprofen axetil combined with TAP block significantly improves postoperative analgesia, reduces the dosage of analgesic agents, accelerates postoperative recovery, and demonstrates a favorable safety profile in patients undergoing LTH.
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2026, Vol. 43 
