替罗非班局部动脉导管溶栓术对脑梗死患者血小板参数及血清S100B、NSE水平的影响<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.07.007

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摘要【目的】探讨替罗非班局部动脉导管溶栓术(TTT)对脑梗死患者血小板参数及血清S100B蛋白(S100B)、神经元特异性烯醇化酶(NSE)水平的影响。【方法】110例脑梗死患者随机分为观察组和对照组,每组55例。对照组行常规药物治疗,观察组在对照组基础上加用替罗非班TTT治疗。比较两组患者的短期疗效,治疗前后各功能相关评分[美国国立卫生研究所脑卒中量表(NIHSS)评分、Fugl-Meyer运动功能评估量表(FMA)评分、日常生活能力Barthel指数(BI)评分]、脑血流指标、血小板参数[血小板计数(PLT)、血小板平均容积(MPV)、血小板分布宽度(PDW)]以及血清S100B、NSE水平。【结果】观察组总有效率高于对照组(P<0.05)。治疗后,两组NIHSS评分较治疗前下降,FMA、BI评分升高(均P<0.05),且观察组NIHSS评分低于对照组,FMA、BI评分高于对照组(P<0.05);两组脑相关动脉血流速度均升高,且观察组高于对照组(P<0.05);两组PLT升高,MPV、PDW下降(P<0.05),且观察组PLT高于对照组,MPV、PDW低于对照组(P<0.05);两组血清S100B、NSE水平均降低,且观察组低于对照组(P<0.05)。【结论】替罗非班TTT治疗脑梗死患者的疗效好,促进患者神经、运动、自理能力恢复,改善脑血流循环,调节血小板参数与血清S100B、NSE水平。

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	张凯华
	杨硕
	刘喜灿

关键词 ：脑梗死, 替罗非班, 血栓溶解疗法, S100蛋白质类, 磷酸丙酮酸水合酶

Abstract：【Objective】 To investigate the effects of tirofiban local intra-arterial catheter thrombolysis (TTT) on platelet parameters and serum levels of S100B protein and neuron-specific enolase (NSE) in patients with cerebral infarction.【Methods】 A total of 110 patients with cerebral infarction were randomly divided into an observation group and a control group, with 55 cases in each group. The control group received standard drug therapy, while the observation group received additional TTT treatment with tirofiban. Short-term efficacy, pre-and post-treatment scores on the National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer Assessment (FMA), and Barthel Index (BI), cerebral blood flow indices, platelet parameters [platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW)], as well as serum levels of S100B and NSE, were compared between the two groups.【Results】 The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). After treatment, NIHSS scores decreased and FMA and BI scores increased in both groups (all P<0.05), with the observation group showing lower NIHSS scores and higher FMA and BI scores compared to the control group (P<0.05). Cerebral artery blood flow indices improved in both groups, with greater improvements in the observation group (P<0.05). PLT increased and both MPV and PDW decreased in the two groups (P<0.05), with the observation group showing higher PLT and lower MPV and PDW than the control group (P<0.05). Serum levels of S100B and NSE decreased in both groups, with lower levels observed in the observation group (P<0.05).【Conclusion】 TTT with tirofiban can effectively enhance therapeutic outcomes in patients with cerebral infarction, promote recovery of neurological, motor, and self-care functions, improve cerebral blood circulation, and regulate platelet parameters and serum levels of S100B and NSE.

Key words： Brain Infarction Tirofiban Thrombolytic Therapy S100 Proteins Phosphopyruvate Hydratase

收稿日期: 2025-04-29

中图分类号:

R743.33

基金资助:^*河南省医学科技攻关计划项目(LHGJ20220857)

引用本文:

张凯华, 杨硕, 刘喜灿. 替罗非班局部动脉导管溶栓术对脑梗死患者血小板参数及血清S100B、NSE水平的影响^*[J]. 医学临床研究, 2025, 42(7): 1127-1130.
ZHANG Kaihua, YANG Shuo, LIU Xican. Effect of Tirofiban Local Intra-Arterial Catheter Thrombolysis on Platelet Parameters, Serum S100B and NSE in Patients with Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1127-1130.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.007 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1127

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