新疆维吾尔族与山东汉族胃癌患者的临床病理特征<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.07.003

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摘要【目的】比较新疆维吾尔族、山东汉族胃癌患者的临床病理特征。【方法】收集2018年1月至2020年12月山东省立第三医院、新疆医科大学第三临床医学院(附属肿瘤医院)手术切除的144例原发性胃癌组织标本,其中山东汉族胃癌94例(汉族组),新疆维吾尔族胃癌患者50例(维吾尔族组)。比较两组患者临床病理特征和胃癌组织中人表皮生长因子受体-2(HER2)蛋白表达情况。【结果】维吾尔族组胃癌平均发病年龄低于汉族组(P<0.05),且维吾尔族组患者40~65岁占比高于汉族组(P<0.05);两组男性胃癌患者占比高于女性患者(P<0.05)。维吾尔族组胃癌发病部位在食管胃结合部占比高于汉族组(P<0.05);维吾尔族组低分化胃癌占比高于汉族组,中分化胃癌占比低于汉族组(P<0.05)。汉族组弥漫型胃癌、肠型胃癌占比高于维吾尔族组(P<0.05),混合型胃癌占比低于维吾尔族组(P<0.05)。维吾尔族组胃癌组织中HER2蛋白 3⁺表达率低于汉族组(P<0.05),HER2蛋白2⁺表达率高于汉族组(P<0.05);维吾尔族组HER2阴性的肠型、混合型胃癌患者占比低于汉族组(P<0.05),汉族组HER2阳性的混合型胃癌患者占比高于维吾尔族组(P<0.05)。HER2蛋白表达差异性与民族、组织学分级、Lauren分型相关(P<0.05)。【结论】新疆维吾尔族、山东汉族胃癌患者具有不同的临床病理特征,不同种族遗传背景的胃癌HER2蛋白表达差异性可能影响患者预后。

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关键词 ：胃肿瘤, 维吾尔族, 汉族, 病理状态, 体征和症状

Abstract：【Objective】To compare the clinicopathological characteristics of patients with gastric carcinoma in Xinjiang Uyghur and Shandong Han ethnic groups. 【Methods】A total of 144 specimens of primary gastric cancer surgically resected in Shandong Provincial Third Hospital and the Third Clinical Medical College of Xinjiang Medical University (Affiliated Cancer Hospital) from January 2018 to December 2020 were collected, including 94 cases of Han ethnicity in Shandong (Han group) and 50 cases of Uyghur ethnicity in Xinjiang (Uyghur ethnicity group). The clinicopathological characteristics and HER2 expression of gastric cancer in the two groups were compared. 【Results】 The average age of onset of gastric cancer in the Uyghur group was lower than that in the Han group, and the proportion of patients aged 40-65 in the Uyghur group was higher than that in the Han group. The proportion of male patients in both groups of gastric cancer patients was higher than that of female patients. The proportion of gastric cancer located at the gastroesophageal junction in the Uyghur group was higher than that in the Han group. The proportion of poorly differentiated gastric cancer in the Uyghur group was higher than that in the Han group, while the proportion of moderately differentiated gastric cancer was lower than that in the Han group. The proportion of diffuse and intestinal-type gastric cancer in the Han group was higher than that in the Uyghur group, while the proportion of mixed gastric cancer was lower than that in the Uyghur group. The expression rate of HER2 protein 3⁺ in gastric cancer tissues of the Uyghur group was lower than that of the Han group, while the expression rate of HER2 protein 2⁺ was higher than the Han group. The number of HER2-negative intestinal and mixed gastric cancer patients in the Uyghur group was lower than in the Han group, while the number of HER2-positive mixed gastric cancer patients with han was higher than in the Uygur group. The difference in HER2 protein expression was correlated with ethnicity, tumor differentiation degree, and Lauren classification (P<0.05). 【Conclusion】Gastric cancer patients of Uyghur ethnicity in Xinjiang and Han ethnicity in Shandong have different clinicopathological characteristics. The differences in HER2 protein expression in gastric cancer with different racial genetic backgrounds may affect the prognosis of patients.

Key words： Stomach Neoplasms Uygur Nationality Han Nationality Pathological Conditions, Signs and Symptoms

收稿日期: 2023-04-20

中图分类号:

R735.2

基金资助:^*山东省医药卫生科技发展计划项目(编号:202101041037);山东省医药卫生科技发展计划项目(编号:202301041288)

引用本文:

杨香山, 于静, 徐保群, 张晶, 于琼, 梁莉萍. 新疆维吾尔族与山东汉族胃癌患者的临床病理特征^*[J]. 医学临床研究, 2025, 42(7): 1112-1115.
YANG Xiangshan, YU Jing, XU Baoqun, et al. Comparison of Clinicopathologic Features of Gastric Carcinoma in Shandong Han and Xinjiang Uygur. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1112-1115.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.003 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1112

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