Abstract：【Objective】To explore the clinical efficacy of sequential azithromycin therapy in the treatment of Mycoplasma pneumoniae pneumonia (MPP) in children. 【Methods】A total of 126 children with MPP diagnosed and treated in our hospital from June 2022 to July 2024 were selected and divided into the effective group (n=98) and the ineffective group (n=28) according to the therapeutic effect of the children. The general information, laboratory tests and imaging examination results of the two groups of children were compared. 【Result】The duration of fever in the effective group was shorter than that in the ineffective group. The hypersensitive C-reactive protein (hs-CRP), clinical pulmonary infection score (CPIS), and pediatric critical illness score (PCIS) in the effective group were lower than those in the ineffective group. The incidence of circulatory system complications and the infection rate of multiple bacteria in the effective group were lower than those in the ineffective group. The differences were statistically significant (P<0.05). The results of multivariate Logistic regression analysis showed that the duration of fever, circulatory system complications, hs-CRP, and PCIS were the influencing factors of the therapeutic effect of sequential azithromycin therapy in children with MPP (P<0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of the combined prediction of fever duration, circulatory system complications, hs-CRP and PCIS for children who were ineffective azithromycin sequential therapy was 0.956, with a sensitivity of 85.7% and a specificity of 99.0%. 【Conclusion】The duration of fever, circulatory system complications, hs-CRP, and PCIS are the influencing factors of the therapeutic effect of sequential azithromycin therapy in children with MPP. Clinically, these factors should be comprehensively considered to formulate individualized treatment plans to improve the therapeutic effect of patients.
刘元超, 李欢欢, 张守亭. 阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的临床疗效[J]. 医学临床研究, 2025, 42(6): 1033-1036.
LIU Yuanchao, LI Huanhuan, ZHANG Shouting. Analysis of Factors Influencing the Efficacy of Azithromycin Sequential Therapy in Children with Mycoplasma Pneumoniae Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1033-1036.
2025, Vol. 42 
