DCE-MRI定量参数与乳腺癌患者ER、PR、HER-2水平的相关性分析

doi:10.3969/j.issn.1671-7171.2025.05.021

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1185 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨动态增强磁共振成像(DCE-MRI)定量参数与乳腺癌患者雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)水平的相关性。【方法】选择2021年5月至2023年5月本院收治的80例乳腺癌患者,所有患者均进行DCE-MRI检查,观察并记录肿瘤特征,包括肿瘤大小、边界、强化方式及淋巴结转移情况,测量并记录定量参数,包括容量转移常数(K_trans)、速率常数(K_ep)、血管外细胞间隙容积比(V_e),检测患者ER、PR、HER-2水平,对比不同ER、PR、HER-2表达水平患者的肿瘤特征、容量特征差异,并采用Spearman相关性分析DCE-MRI定量参数与乳腺癌患者ER、PR、HER-2表达水平的相关性。【结果】肿瘤直径＜25 mm的HER-2阳性表达率低于肿瘤直径≥25 mm,差异有统计学意义(P<0.05);边界不规则的ER、PR阳性表达率低于边界边缘毛刺样,差异有统计学意义(P<0.05);有淋巴结转移的ER、PR、HER-2阳性表达率高于无淋巴结转移,差异有统计学意义(P<0.05)。不同ER表达情况的乳腺癌患者K_trans、K_ep、V_e比较,差异无统计学意义(P>0.05);PR阳性表达的乳腺癌患者K_trans、K_ep高于PR阴性表达者,差异有统计学意义(P<0.05);HER-2阳性表达的乳腺癌患者K_ep高于HER-2阴性表达,差异有统计学意义(P<0.05)。Spearman相关性分析显示,K_trans、K_ep与PR表达水平呈正相关(P<0.05),K_ep与HER-2表达水平呈正相关(P<0.05)。【结论】DCE-MRI定量参数K_trans、K_ep与PR表达水平密切相关,临床可通过对乳腺癌患者进行DCE-MRI检查,从而为临床初步评估患者病情及后续进行综合治疗提供参考。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	吴学芬

关键词 ：乳腺肿瘤, 磁共振成像, 受体,雌激素, 受体,孕酮, ErbB受体

Abstract：【Objective】To investigate the correlation between quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and the levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) in breast cancer patients.【Methods】A total of 80 breast cancer patients admitted to both chambers from May 2021 to May 2023 were selected. All patients underwent DCE-MRI examination to observe and record tumor characteristics, including tumor size, boundary, enhancement mode and lymph node metastasis. Quantitative parameters, including volume transfer constant (K_trans), rate constant (K_ep) and extravascular cell space volume ratio (V_e), were measured and recorded, and the levels of ER, PR and HER-2 were detected. The differences in tumor characteristics and volume characteristics of patients with different ER, PR and HER-2 expression levels were compared. Spearman correlation was used to analyze the correlation between DCE-MRI quantitative parameters and the expression of ER, PR and HER-2 in breast cancer patients. 【Results】The positive expression rate of HER-2 in tumor diameter <25 mm was lower than ≥25 mm, and the difference was statistically significant (P<0.05). The positive expression rates of ER and PR in irregular borderlines were lower than those in burr borderlines, with statistical significance (P<0.05). The positive expression rates of ER, PR and HER-2 in patients with lymph node metastasis were higher than those without lymph node metastasis, and the difference was statistically significant (P<0.05). There was no significant difference in K_trans, K_ep and V_e among breast cancer patients with different ER expression levels (P>0.05). K_trans and K_ep in breast cancer patients with positive expression of PR were higher than those with negative expression of PR, and the difference was statistically significant (P<0.05). The K_ep of breast cancer patients with positive expression of HER-2 was higher than that of positive and negative expression of HER-2, and the difference was statistically significant (P<0.05). Spearman correlation analysis showed that the expression level of K_trans and K_ep was positively correlated with PR (P<0.05), and the expression level of K_ep was positively correlated with HER-2 (P<0.05). 【Conclusion】DCE-MRI quantitative parameters K_trans and K_ep are closely related to the expression level of PR. Clinical DCE-MRI examination can be performed on breast cancer patients, so as to provide references for preliminary clinical assessment of the patient's condition and subsequent comprehensive treatment.

Key words： Breast Neoplasms Magnetic Resonance Imaging Receptors, Estrogen Receptors,Progesterone ErbB Receptors

收稿日期: 2023-07-18

中图分类号:

R737.9

引用本文:

吴学芬. DCE-MRI定量参数与乳腺癌患者ER、PR、HER-2水平的相关性分析[J]. 医学临床研究, 2025, 42(5): 809-812.
WU Xuefen. Correlation Analysis of DCE-MRI Quantitative Parameters with ER, PR and HER-2 Levels in Patients with Breast Cancer. JOURNAL OF CLINICAL RESEARCH, 2025, 42(5): 809-812.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.05.021 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I5/809

[1] 钟明浩,杨志企,姚纯,等.定量DCE-MRI参数、ADC值与乳腺癌p53、CK56表达状态相关性研究[J].国际医学放射学杂志, 2021, 44(4):403-407.
[2] 黄婧潇,吴朋,孙静宜,等.DCE-MRI定量参数全域直方图分析法在乳腺肿瘤鉴别诊断中的应用价值[J].山西医科大学学报, 2019, 50(3):347-353.
[3] 周意明,徐筑津,华彬,等.比较乳腺动态对比增强MRI定量和半定量参数预测乳腺癌新辅助化疗疗效的价值[J].实用放射学杂志, 2020, 36(3):396-400.
[4] 余哲歆,刘进康,周晖,等.体素内不相干运动与动态增强对乳腺癌免疫组化指标的预测价值[J].中国医学影像学杂志, 2019, 27(7):522-526.
[5] 王琳琳,刘源源.3.0T DCE-MRI定量参数联合外周血micro RNA21t和金属硫蛋白-1E对乳腺癌诊断价值[J].放射学实践, 2020, 35(10):1263-1268.
[6] 王涛,江泽飞.美国临床肿瘤学会和美国病理医师学院乳腺癌激素受体检测指南的临床意义[J].中华病理学杂志,2010,39(11):721-722.
[7] 谭雅文,刘繁,孙诗瑶,等. 联合使用多种数据库分析KIAA0101对三阴性乳腺癌的影响[J].中国现代手术学杂志, 2021,25(1): 1-6.
[8] 王建国, 李绍杰. 肿瘤相关巨噬细胞和细胞因子表达对三阴乳腺癌患者预后的影响[J].中国现代手术学杂志, 2021, 21(2): 85-89.
[9] 马烨,李锋,张双,等.动态增强磁共振成像在乳腺癌诊断中的临床价值及联合Her-2和Ki-67检测对其预后评估的价值研究[J].中国医学装备, 2022,19(3):71-75.
[10] 王志远,吴海龙,李淑豪,等.IVIM-DWI与DCE-MRI定量参数鉴别乳腺良恶性肿瘤的对照研究[J].放射学实践, 2021, 36(12):1514-1519.
[11] 杨文强,刘敏,唐铁雷,等.TCH新辅助化疗方案治疗HER-2阳性乳腺癌的疗效及对患者ER、PR、HER-2及Ki67表达的影响[J].海南医学, 2020, 31(20):2598-2601.
[12] 陶秀霞,朱峰岭,汪建文.乳腺癌钼靶X线恶性钙化征象与ER、PR和HER-2、Ki-67表达的关系[J].山东医药, 2020, 60(7):64-66.
[13] 李晏, 郑晓林, 刘碧华, 等.MRI动态增强定量参数对乳腺非肿块样强化良恶性病变的鉴别诊断价值[J].海南医学, 2020,31(10): 1283-1287.
[14] 王倩, 刘万花, 王瑞, 等.3.0T动态增强 MRI 定量参数、表观扩散系数与乳腺癌预后因子及分子分型的相关性[J].中国医学影像学杂志, 2019, 27(7): 517-521.
[15] 黄秒, 苏丹柯, 金观桥,等.乳腺癌X线摄影表现与ER、PR和HER-2表达的相关性研究[J].实用放射学杂志, 2020, 36(2):214-218.
[16] 解婷婷,樊晓.改良PCH方案对HER-2阳性乳腺癌的疗效及与ER、PR水平的关系[J].实用癌症杂志, 2021, 36(12):2023-2027.
[17] 储荣先,彭梅.浸润性乳腺癌患者组织ER、PR及HER-2与超声影像的关系分析[J].中国超声医学杂志, 2021, 37(9):986-989.