Abstract：【Objective】 To explore the correlation between blood biochemical indicators and kidney injury in patients with diabetes combined with hypertension.【Methods】 A total of 320 patients with diabetes combined with hypertension were divided into a non-injury group (152 cases) and a kidney injury group (168 cases) based on the presence or absence of kidney injury. All patients underwent relevant blood biochemical tests, and the correlation between various indicators and the occurrence of kidney injury was analyzed. Multi-factor logistic regression was used to identify the influencing factors.【Results】 There was no significant difference in fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) between the two groups (P>0.05). The levels of glycated hemoglobin (HbA1c), cystatin C (cys C), serum creatinine (Scr), and serum β2-microglobulin (β2-MG) in the kidney injury group were higher than those in the non-injury group (P<0.05). Serum HbA1c, cys C, Scr, and β2-MG levels were positively correlated with the occurrence of kidney injury in patients with diabetes combined with hypertension (P<0.05). Logistic regression analysis showed that HbA1c, cys C, Scr, and β2-MG levels were important influencing factors for the occurrence of kidney injury (OR>1, P<0.05).【Conclusion】 Serum levels of HbA1c, cys C, Scr, and β2-MG are significantly positively correlated with the occurrence of kidney injury in patients with diabetes combined with hypertension, and these indicators are important influencing factors for occurrence of kidney injury, which can provide reference for clinical practice.
2025, Vol. 42 
